C
Cliff Wong
Researcher at Microsoft
Publications - 30
Citations - 3556
Cliff Wong is an academic researcher from Microsoft. The author has contributed to research in topics: Computer science & Drug delivery. The author has an hindex of 10, co-authored 26 publications receiving 2989 citations. Previous affiliations of Cliff Wong include Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Compact high-quality CdSe–CdS core–shell nanocrystals with narrow emission linewidths and suppressed blinking
Ou Chen,Jing Zhao,Vikash P. Chauhan,Jian Cui,Cliff Wong,Daniel K. Harris,He Wei,Hee-Sun Han,Dai Fukumura,Rakesh K. Jain,Moungi G. Bawendi +10 more
TL;DR: In this paper, the synthesis of high-quality CdSe-CdS core-shell quantum dots in an optimized process that maintains a slow growth rate of the shell through the use of octanethiol and cadmium oleate as precursors.
Journal ArticleDOI
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Cliff Wong,Triantafyllos Stylianopoulos,Jian Cui,John D. Martin,Vikash P. Chauhan,Wen Jiang,Zoran B. Popović,Rakesh K. Jain,Moungi G. Bawendi,Dai Fukumura +9 more
TL;DR: In vivo circulationHalf-life and intratumoral diffusion measurements indicate that the multistage nanoparticles exhibited both the long circulation half-life necessary for the EPR effect and the deep tumor penetration required for delivery into the tumor's dense collagen matrix.
A Nanoparticle Size Series for In Vivo Fluorescence Imaging
Zoran B. Popović,Wenhao Liu,Vikash P. Chauhan,Jungmin Lee,Cliff Wong,Andrew B. Greytak,Numpon Insin,Daniel G. Nocera,Dai Fukumura,Rakesh K. Jain,Moungi G. Bawendi +10 more
TL;DR: Any design of nanoparticle vectors for cancer therapy or imaging must take into account the interaction of the nanoparticles with the tumor microenvironment, and size, charge, and shape have been shown to dominate this interaction.
Journal ArticleDOI
A nanoparticle size series for in vivo fluorescence imaging
Zoran B. Popović,Wenhao Liu,Vikash P. Chauhan,Jungmin Lee,Cliff Wong,Andrew B. Greytak,Numpon Insin,Daniel G. Nocera,Dai Fukumura,Rakesh K. Jain,Moungi G. Bawendi +10 more
TL;DR: In this paper, the interaction of the nanoparticles with the tumor microenvironment has been studied, and size, charge, and shape have been shown to dominate the interaction between nanoparticles and the microenvironment.
Journal ArticleDOI
Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand
Wenhao Liu,Andrew B. Greytak,Jungmin Lee,Cliff Wong,Jongnam Park,Lisa F. Marshall,Wen Jiang,Peter N. Curtin,Alice Y. Ting,Daniel G. Nocera,Dai Fukumura,Rakesh K. Jain,Moungi G. Bawendi +12 more
TL;DR: In this article, a new class of polymeric ligands for quantum dot (QD) water solubilization was proposed to yield biocompatible and derivatizable QDs with compact size (∼10−12 nm diameter), high quantum yields (>50%), excellent stability across a large pH range (pH 5−105), and low nonspecific binding.