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Wen Jiang
Researcher at University of Texas Southwestern Medical Center
Publications - 144
Citations - 12075
Wen Jiang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cancer & Immunotherapy. The author has an hindex of 44, co-authored 136 publications receiving 9006 citations. Previous affiliations of Wen Jiang include Stanford University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Nanoparticle-mediated cellular response is size-dependent
TL;DR: It is shown that gold and silver nanoparticles coated with antibodies can regulate the process of membrane receptor internalization and show that nanoparticles should no longer be viewed as simple carriers for biomedical applications, but can also play an active role in mediating biological effects.
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Multistage nanoparticle delivery system for deep penetration into tumor tissue
Cliff Wong,Triantafyllos Stylianopoulos,Jian Cui,John D. Martin,Vikash P. Chauhan,Wen Jiang,Zoran B. Popović,Rakesh K. Jain,Moungi G. Bawendi,Dai Fukumura +9 more
TL;DR: In vivo circulationHalf-life and intratumoral diffusion measurements indicate that the multistage nanoparticles exhibited both the long circulation half-life necessary for the EPR effect and the deep tumor penetration required for delivery into the tumor's dense collagen matrix.
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Phagocytosis checkpoints as new targets for cancer immunotherapy.
TL;DR: An improved understanding of the tumour-intrinsic processes that inhibit essential immune surveillance processes, such as phagocytosis and innate immune sensing, could pave the way for the development of highly effective combination immunotherapy strategies that modulate both innate and adaptive antitumour immune responses.
Journal ArticleDOI
Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking.
TL;DR: This review aims to summarize the recent progress in the design and preparation of SPions as cellular MRI probes, to discuss their applications and current problems facing in stem cell labeling and tracking, and to offer perspectives and solutions for the future development of SPIONs in this field.
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Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.
Zhaogang Yang,Zhaogang Yang,Junfeng Shi,Jing Xie,Yifan Wang,Jingyao Sun,Tongzheng Liu,Yarong Zhao,Xiuting Zhao,Xinmei Wang,Yifan Ma,Veysi Malkoc,Chi-Ling Chiang,Weiye Deng,Yuanxin Chen,Yuan Fu,Kwang J. Kwak,Yamin Fan,Chen Kang,Changcheng Yin,June Rhee,Paul Bertani,Jose Otero,Wu Lu,Kyuson Yun,Andrew S. Lee,Wen Jiang,Lesheng Teng,Betty Y.S. Kim,Betty Y.S. Kim,L. James Lee +30 more
TL;DR: In this article, a cellular-nanoporation method for the production of large quantities of exosomes containing therapeutic mRNAs and targeting peptides was reported, and the exosome-containing exosomal mRNA transcripts were shown to restore tumour-suppressor function, enhanced inhibition of tumour growth and increased survival.