Collins Stephen D

TL;DR: Vagus nerve stimulation is an effective and safe adjunctive treatment for patients with refractory partial-onset seizures and represents the advent of a new, nonpharmacologic treatment for epilepsy.

TL;DR: In this paper, the authors compared the efficacy and safety of therapeutic (high) vagus nerve stimulation with less (low) stimulation and found that the high stimulation was associated with more voice alteration and dyspnea.

TL;DR: WWE face health issues for which there is no available outcome literature to guide decision making, and there is a biologic basis for recommendations concerning contraception, folate supplementation, vitamin K use in pregnancy, breast-feeding, metabolic bone disease, catamenial epilepsy, and reproductive endocrine disorders.

TL;DR: Hup A might provide a novel therapeutic strategy for increasing seizure resistance in DS and GEFS+, and more broadly, in other forms of refractory epilepsy, as well as muscarinic and GABAA receptors play a role in Hup A-mediated seizure protection.

TL;DR: This report reports the largest prospective long‐term study of VNS to date, in 114 patients, that has demonstrated a cumulative improvement in efficacy at 1 year.