C
Concepcion Almoguera
Researcher at Stony Brook University
Publications - 7
Citations - 3752
Concepcion Almoguera is an academic researcher from Stony Brook University. The author has contributed to research in topics: Carcinogenesis & Adenocarcinoma. The author has an hindex of 5, co-authored 6 publications receiving 3682 citations. Previous affiliations of Concepcion Almoguera include State University of New York System.
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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
Concepcion Almoguera,Darryl Shibata,Kathleen Forrester,John Martin,Norman Arnheim,Manuel Perucho +5 more
TL;DR: It is concluded that c-K-ras somatic mutational activation is a critical event in the oncogenesis of most, if not all, human cancers of the exocrine pancreas.
Journal ArticleDOI
Detection of high incidence of K- ras oncogenes during human colon tumorigenesis
Kathleen Forrester,Concepcion Almoguera,Kyuhyung Han,Kyuhyung Han,William E. Grizzle,Manuel Perucho +5 more
TL;DR: RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12, and evidence for ras mutational activation in premalignant tissue was obtained.
Journal ArticleDOI
A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells
TL;DR: A method to detect and characterize mutations in ras genes that is based on the ability of pancreatic ribonuclease (RNase A; EC 3.1.5) to cleave RNA heteroduplexes containing single-base mismatches is reported.
Journal ArticleDOI
Detection of c-K-ras Mutations in Fine Needle Aspirates from Human Pancreatic Adenocarcinomas
Darryl Shibata,Concepcion Almoguera,Kathleen Forrester,Jordan Dunitz,Sue Ellen Martin,Michele M. Cosgrove,Manuel Perucho,Norman Arnheim +7 more
TL;DR: Mutant c-K-ras genes were found at the time of initial clinical presentation in the majority of pancreatic adenocarcinomas, suggesting an important role of the mutation in oncogenesis.
Journal Article
The c-K-ras gene and human cancer (review).
S. Kahn,Fumiichiro Yamamoto,Concepcion Almoguera,Edward Winter,Kathleen Forrester,Juan Jordano,Manuel Perucho +6 more
TL;DR: A significant number of human tumors from diverse histological origins contain c-K-ras oncogenes which have been activated by somatic point mutations resulting in single amino acids substitutions in the encoded p21 ras protein this paper.