Cong Wang

TL;DR: Clinically, CASC2 underexpression and miR-367 overexpression were closely correlated with the metastasis-associated clinicopathologic features and it is concluded that the CASC 2/miR- 367/FBXW7 axis may be a ponderable and promising therapeutic target for HCC.

TL;DR: It is reported for the first time that D SCR8 activates Wnt/β-catenin signal pathway to promote HCC progression by DSCR8/miR-485-5p/FZD7 axis, providing promising and valuable strategies for targeted therapy of HCC.

TL;DR: The findings indicated that HSCs-derived COMP collaborated with CD36 and subsequently played an essential role in MEK/ERK and PI3K/AKT-mediated HCC progression, which might act as a promising target for the diagnosis and treatment of aggressive HCC.

TL;DR: It is shown that IL-6/STAT3 signaling was activated aberrantly in HCC tissues and correlated with poor post-surgical outcome and PCAF, a well-known acetyltransferase, was revealed to acetylate cytoplasmic STAT3 protein directly and regulate TIMP-1 expression negatively in Huh7 cells.

TL;DR: Results indicated that miR-542-3p functioned as a tumor suppressor gene in regulating the EMT and metastasis of HCC via targeting UBE3C, and may represent a novel potential therapeutic target and prognostic marker for HCC.