Z
Zhikui Liu
Researcher at Xi'an Jiaotong University
Publications - 68
Citations - 2688
Zhikui Liu is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: microRNA & Protein kinase B. The author has an hindex of 25, co-authored 53 publications receiving 1905 citations. Previous affiliations of Zhikui Liu include Mayo Clinic.
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Journal ArticleDOI
Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis.
Yufeng Wang,Zhikui Liu,Bowen Yao,Qing Li,Liang Wang,Cong Wang,Changwei Dou,Meng Xu,Qingguang Liu,Kangsheng Tu +9 more
TL;DR: Clinically, CASC2 underexpression and miR-367 overexpression were closely correlated with the metastasis-associated clinicopathologic features and it is concluded that the CASC 2/miR- 367/FBXW7 axis may be a ponderable and promising therapeutic target for HCC.
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HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma
Qiuran Xu,Jianfeng Tu,Changwei Dou,Jun Zhang,Liu Yang,Xin Liu,Kefeng Lei,Zhikui Liu,Yufeng Wang,Lijie Li,Hangxing Bao,Jiahui Wang,Kangsheng Tu +12 more
TL;DR: HSP90 potentiates the glycolysis and proliferation, reduces the apoptosis and thus enhances the growth of HCC cells through PKM2, and a combination of these proteins could strongly predict the poor prognosis of H CC patients.
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P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.
Changwei Dou,Changwei Dou,Zhikui Liu,Zhikui Liu,Kangsheng Tu,Kangsheng Tu,Hongbin Zhang,Chen Chen,Usman Yaqoob,Yuanguo Wang,Jialing Wen,Jan M. van Deursen,Delphine Sicard,Daniel J. Tschumperlin,Hongzhi Zou,Wei Chien Huang,Raul Urrutia,Vijay H. Shah,Ningling Kang +18 more
TL;DR: Liver stiffness to activate HSC differentiation into myofibroblasts, which required nuclear accumulation of p300, and RNA sequencing and chromatin immunoprecipitation-quantitative polymerase chain reaction were used to identify HSC genes that changed expression levels in response to stiffness.
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MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway.
Qiuran Xu,Xin Liu,Zhikui Liu,Zhenyu Zhou,Yufeng Wang,Jianfeng Tu,Lijie Li,Hangxing Bao,Liu Yang,Kangsheng Tu +9 more
TL;DR: It was found that the expression of miR-1296 was reduced in HCC tissues and cell lines, and it was associated with metastasis and recurrence of HCC, and the promoting effects of hypoxia on metastasis-to-mesenchymal transition (EMT) and EMT of H CC cells were reversed by miR -1296.
Journal ArticleDOI
Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis
Jinhang Gao,Jinhang Gao,Bo Wei,Bo Wei,Thiago M. De Assuncao,Zhikui Liu,Xiao Hu,Samar H. Ibrahim,Shawna A. Cooper,Sheng Cao,Vijay H. Shah,Enis Kostallari +11 more
TL;DR: In HSCs, autophagy inhibits fibrogenic EV release which can attenuate liver fibrosis, and an mTOR (mammalian target of rapamycin) signaling molecule to be regulated by SHP2 and PDGF is identified.