Conrad Weichbrodt

TL;DR: In this paper, the authors presented the X-ray crystal structure as well as solid-state NMR spectroscopy, electrophysiology, and MD simulations of human dermcidin in membranes that reveal the antibiotic mechanism of this major human antimicrobial, found to suppress Staphylococcus aureus growth on the epidermal surface.

TL;DR: Spectroelectrochemical approaches probe the voltage-induced molecular structure changes of human VDAC1 (hVDAC1) embedded in a tethered bilayer lipid membrane on a nanostructured Au electrode to identify spectral changes which may be associated with the transition from the open to the "closed" states.

TL;DR: An electrical equivalent circuit was developed to fully describe the electrical properties of the gramicidin D-doped membrane system, which allowed us to extract the membrane resistance but also the mass transport in bulk solution as a function of the monovalent cation concentration in solution.

TL;DR: The submicrosecond VDAC-1 voltage response shows intrinsic structural changes that explain the role of key gating amino acids and support some of the current gating hypotheses, including asymmetric barrel distortion, its interaction with the membrane, and significant displacement of N-α amino acids.

TL;DR: The CardioExcyte 96, a system providing a combination of Electric Impedance Spectroscopy (EIS) as well as Electric Field Potential (EFP) readout for a network of diverse cells which is exemplified by toxicity effects util izing reference compounds such as Dofetilide or Paracetamol is presented.