C
Constance Scharff
Researcher at Free University of Berlin
Publications - 84
Citations - 7168
Constance Scharff is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Zebra finch & FOXP2. The author has an hindex of 34, co-authored 81 publications receiving 6699 citations. Previous affiliations of Constance Scharff include Rockefeller University & Adelphi University.
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Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation
Vera M. Kalscheuer,Kristine K. Freude,Luciana Musante,Lars Riff Jensen,Helger G. Yntema,Jozef Gecz,Abdelaziz Sefiani,Kirsten Hoffmann,Bettina Moser,Stefan A. Haas,Ulf Gurok,Sebastian Haesler,Beatriz Aranda,Arpik Nshedjan,Andreas Tzschach,Nils Hartmann,Tim-Christoph Roloff,Sarah A. Shoichet,Olivier Hagens,Jiong Tao,Hans van Bokhoven,Gillian Turner,Jamel Chelly,Claude Moraine,Jean-Pierre Fryns,Ulrike A. Nuber,Maria Hoeltzenbein,Constance Scharff,Harry Scherthan,Steffen Lenzner,Ben C.J. Hamel,Susann Schweiger,Hans-Hilger Ropers +32 more
TL;DR: The authors found mutations in the gene PQBP1 in 5 of 29 families with nonsyndromic and syndromic forms of X-linked mental retardation (XLMR) and shed more light on the pathogenesis of this common disorder.
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Challenges for brain repair: insights from adult neurogenesis in birds and mammals.
Fiona Doetsch,Constance Scharff +1 more
TL;DR: This work compares adult neurogenesis in birds and mammals and reviews recent studies on the glial identity of stem cells that generate new neurons, the different modes of migration used by the newly generated neurons to reach their destinations, and how these systems respond to experimentally induced cell death.
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The Songbird as a Model for the Generation and Learning of Complex Sequential Behaviors
Michale S. Fee,Constance Scharff +1 more
TL;DR: This review presents new techniques, experiments, and findings in areas where songbirds have made significant contributions toward understanding of some of the most fundamental questions in neuroscience.
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Gene expression changes in the course of neural progenitor cell differentiation
Ulf Gurok,Christine Steinhoff,Bettina Lipkowitz,Hans-Hilger Ropers,Constance Scharff,Ulrike A. Nuber +5 more
TL;DR: The authors' results provide new insights into the genetic program of neural progenitor differentiation and give strong hints to as yet unknown cellular communications within the adult subventricular zone stem cell niche.
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Diminished FoxP2 Levels Affect Dopaminergic Modulation of Corticostriatal Signaling Important to Song Variability
TL;DR: It is shown that FoxP2 knockdown in the songbird striatum disrupts developmental and social modulation of song variability, which may impede song and speech development by disrupting reinforcement learning mechanisms.