Constantinos Christodoulides

TL;DR: Manipulating the WNT pathway to alter adipose cellular makeup constitutes an attractive drug-development target to combat obesity-associated metabolic complications.

TL;DR: In this article, quantitative real-time PCR has been used in human tissue to demonstrate that PGC1alpha mRNA levels in subcutaneous fat are three-fold lower in morbidly obese than in slim subjects.

TL;DR: While the pedigree analysis in the case of C256Y WNT10B does not provide definitive proof of a causal link of this variant with obesity, the finding of a non-functioning WNT 10B allele in a human family affected by obesity should encourage further study of this gene in other obese populations.

TL;DR: The results indicate that insulin resistance associated with ablation of PPARgamma2 is not the result of lipodystrophy and suggests a specific role for PPAR Gamma2 in maintaining insulin sensitivity independently of its effects on adipogenesis, and raises the intriguing notion that PPARGamma2 may be necessary for the adverse effects of a high-fat diet on carbohydrate metabolism.

TL;DR: The involvement of Dkk1 in human but not murine adipogenesis indicates that inter-species differences exist in the molecular control of this process, and further knowledge of the pathways involved specifically in human adipocyte differentiation might ultimately be of clinical relevance.