C
Cornelia Rüb
Researcher at University of Bonn
Publications - 13
Citations - 793
Cornelia Rüb is an academic researcher from University of Bonn. The author has contributed to research in topics: Mitochondrion & PINK1. The author has an hindex of 8, co-authored 13 publications receiving 630 citations.
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Journal ArticleDOI
α-Synuclein Is Localized to Mitochondria-Associated ER Membranes
Cristina Guardia-Laguarta,Estela Area-Gomez,Cornelia Rüb,Yuhui Liu,Jordi Magrané,Dorothea Becker,Wolfgang Voos,Eric A. Schon,Serge Przedborski +8 more
TL;DR: Novel results indicate that wild-type α-syn localizes to the MAM and modulates mitochondrial morphology, and that these behaviors are impaired by pathogenic mutations in α- syn, which operates downstream of the mitochondrial fusion/fission machinery.
Journal ArticleDOI
Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy
Maja A. Fedorowicz,Rosa L. A. de Vries‐Schneider,Cornelia Rüb,Dorothea Becker,Yong Huang,Chun Zhou,Dana M. Alessi Wolken,Wolfgang Voos,Yuhui Liu,Serge Przedborski +9 more
TL;DR: It is shown that the PINK1 main cleavage product, PINK152, after being generated inside mitochondria, can exit these organelles and localize to the cytosol, where it is not only destined for degradation by the proteasome but binds to Parkin.
Journal ArticleDOI
Mitochondrial quality control by the Pink1/Parkin system
TL;DR: Recent advances in knowledge of the functional role of the Pink1/Parkin system in preventing the accumulation of damaged mitochondria by mitophagy are summarized.
Journal ArticleDOI
Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process
TL;DR: The observation of insoluble coaggregates between preproteins and Aβ peptides provides a biochemical explanation for mitochondrial dysfunction typically observed in AD-affected cells.
Journal ArticleDOI
Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy.
Kerstin Hallmann,Alexei P. Kudin,Gábor Zsurka,Cornelia Kornblum,Jens Reimann,Burkhard Stüve,Stephan Waltz,Elke Hattingen,Holger Thiele,Peter Nürnberg,Cornelia Rüb,Wolfgang Voos,Jens Kopatz,Harald Neumann,Wolfram S. Kunz +14 more
TL;DR: It is demonstrated that COX8A is indispensable for function of human complex IV and its mutation causes human disease.