Corneliu A. Bodea

TL;DR: Autism's genetic architecture is reached: its narrow-sense heritability is ∼52.4%, with most due to common variation, and rare de novo mutations contribute substantially to individual liability, yet their contribution to variance in liability, 2.6%, is modest compared to that for heritable variation.

TL;DR: Standard gene-based tests will require much larger samples of cases and controls before being effective for gene discovery, even for a disorder like ASD, according to results from whole-exome sequencing of 1,039 subjects diagnosed with autism spectrum disorders and 870 controls selected from the NIMH repository.

TL;DR: This work calls this concept the Universal Control Repository Network (UNICORN), a means to perform association analyses without necessitating direct access to individual-level control data, and demonstrates how it controls false positives, provides power similar to that achieved when all control data are directly accessible, and enhances power when controlData are limiting or even imperfectly matched ancestrally.

TL;DR: In this paper, the authors presented how the simulations were introduced in a Master degree program on Project Management, in project planning and controlling module, based on an agent-based model of the project resource leveling process.

TL;DR: Several regions of the genome exhibited substantial excess of shared haplotypes for affected individuals, including 3p21, 3p12, 4q28, and 5q23-q31, and two regions showed significant linkage by traditional LOD score analysis and could harbor variants of more sizeable risk for psychosis or a multiplicity of risk variants.