C
Costantina Sambani
Researcher at National Centre of Scientific Research "Demokritos"
Publications - 1
Citations - 254
Costantina Sambani is an academic researcher from National Centre of Scientific Research "Demokritos". The author has contributed to research in topics: Chromosomal translocation & Cellular differentiation. The author has an hindex of 1, co-authored 1 publications receiving 251 citations.
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Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
Marina Bousquet,Cathy Quelen,Roberto Rosati,Véronique Mansat-De Mas,Véronique Mansat-De Mas,Roberta La Starza,Christian Bastard,Eric Lippert,Pascaline Talmant,Marina Lafage-Pochitaloff,Dominique Leroux,Carine Gervais,Franck Viguié,Jean-Luc Laï,Christine Terré,Berna Beverlo,Costantina Sambani,Anne Hagemeijer,Peter Marynen,Georges Delsol,Georges Delsol,Nicole Dastugue,Cristina Mecucci,Pierre Brousset,Pierre Brousset +24 more
TL;DR: The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML and it is shown that this translocation is associated with a strong up-regulation of miR-125b, which may represent a new mechanism of myeloid cell transformation.