M
Marina Bousquet
Researcher at University of Toulouse
Publications - 28
Citations - 1540
Marina Bousquet is an academic researcher from University of Toulouse. The author has contributed to research in topics: Leukemia & Chromosomal translocation. The author has an hindex of 16, co-authored 28 publications receiving 1398 citations. Previous affiliations of Marina Bousquet include Texas A&M University & French Institute of Health and Medical Research.
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Journal ArticleDOI
MicroRNA miR-125b causes leukemia
TL;DR: It is shown that overexpression of miR-125b is sufficient both to shorten the latency of BCR-ABL–induced leukemia and to independently induce leukemia in a mouse model, suggesting that miR -125b confers a proliferative advantage to the leukemic cells.
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Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
Marina Bousquet,Cathy Quelen,Roberto Rosati,Véronique Mansat-De Mas,Véronique Mansat-De Mas,Roberta La Starza,Christian Bastard,Eric Lippert,Pascaline Talmant,Marina Lafage-Pochitaloff,Dominique Leroux,Carine Gervais,Franck Viguié,Jean-Luc Laï,Christine Terré,Berna Beverlo,Costantina Sambani,Anne Hagemeijer,Peter Marynen,Georges Delsol,Georges Delsol,Nicole Dastugue,Cristina Mecucci,Pierre Brousset,Pierre Brousset +24 more
TL;DR: The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML and it is shown that this translocation is associated with a strong up-regulation of miR-125b, which may represent a new mechanism of myeloid cell transformation.
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The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.
Marina Bousquet,Cathy Quelen,Veronique De Mas,Eliane Duchayne,Blandine Roquefeuil,Georges Delsol,Guy Laurent,Nicole Dastugue,Pierre Brousset +8 more
TL;DR: This new translocation identifies JAK2 as a possible therapeutic target for compounds with antityrosine kinase activity, and suggests that the putative protein displays the coiled-coil domains of PCM1 and the tyrosine Kinase domain of J AK2.
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The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia
Nathalie Gallay,C Dos Santos,C Dos Santos,Lise Cuzin,Marina Bousquet,Marina Bousquet,V Simmonet Gouy,Claire Chaussade,Michel Attal,Bernard Payrastre,Bernard Payrastre,Cécile Demur,Cécile Demur,Christian Recher,Christian Recher +14 more
TL;DR: The specific Akt inhibitor, Akti-1/2, inhibited cell proliferation and clonogenic properties, and induced apoptosis in AML cells with high- risk cytogenetics, suggesting that Akt may represent a therapeutic target in high-risk AML.
Journal ArticleDOI
Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations
Marina Bousquet,Céline Noirot,Franck Accadbled,J. Sales de Gauzy,Marie Pierre Castex,Pierre Brousset,Pierre Brousset,Anne Gomez-Brouchet,Anne Gomez-Brouchet +8 more
TL;DR: This study suggests that bone oncogenesis driven by TP53 or RB1 mutations occurs on a background of relative genetic stability and that the dedifferentiated OS subtype represents a clinico-pathological entity with distinct oncogenic mechanisms and thus requires different therapeutic management.