Carine Gervais

TL;DR: The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML and it is shown that this translocation is associated with a strong up-regulation of miR-125b, which may represent a new mechanism of myeloid cell transformation.

TL;DR: In vitro experiments revealed that miR-125b was able to block monocytic and granulocytic differentiation of leukemic cells and primary CD34+ human blasts and may represent a new mechanism of myeloid cell transformation and myeloids neoplasms carrying the t(2;11) translocation define a new clinico-pathological entity.

TL;DR: The analysis of the clonal structure in these cases suggests that the mutation order in the Nup98-rearranged pediatric AML begins with the NUP98 rearrangement leading to epigenetic dysregulations then followed by mutations of critical hematopoietic transcription factors and finally, activation of the FLT3 signaling pathway.

TL;DR: Thirty cases of acute myeloid leukaemia with MYST histone acetyltransferase 3 (MYST3) rearrangement were collected in a retrospective study from 14 centres in France and Belgium, and particular clinical, cytologic, cytogenetic, molecular and prognostic characteristics may have allowed an individualization into the World Health Organization classification.

TL;DR: The best indicator for excellent outcome was ploidy assessed by karyotype because patients with 58-66 chromosomes stood every chance of being cured with less-intensive therapy, and MNC remained the strongest factor.