C
Courtney A. Lovejoy
Researcher at Vanderbilt University
Publications - 14
Citations - 1474
Courtney A. Lovejoy is an academic researcher from Vanderbilt University. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 11, co-authored 12 publications receiving 1259 citations. Previous affiliations of Courtney A. Lovejoy include Mayo Clinic & Rockefeller University.
Papers
More filters
Journal ArticleDOI
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Courtney A. Lovejoy,Wendi Li,Steven Reisenweber,Supawat Thongthip,Joanne Bruno,Titia de Lange,Saurav De,John H.J. Petrini,Patricia Sung,Maria Jasin,Joseph Rosenbluh,Yaara Zwang,Yaara Zwang,Barbara A. Weir,Charlie Hatton,Elena Ivanova,Laura E. MacConaill,Megan Hanna,William C. Hahn,William C. Hahn,Neal F. Lue,Roger R. Reddel,Roger R. Reddel,Yuchen Jiao,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Alan K. Meeker +27 more
TL;DR: It is shown that loss of ATRX protein and mutations in the ATRRX gene are hallmarks of ALT–immortalized cell lines, and these attributes will facilitate the diagnosis and treatment ofALT positive human cancers.
Journal ArticleDOI
Common mechanisms of PIKK regulation
Courtney A. Lovejoy,David Cortez +1 more
TL;DR: Common regulatory themes are outlined and it is suggested how discoveries about the regulation of one PIKK can be informative for the other family members.
Journal ArticleDOI
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
TL;DR: SMARCAL1 is a replication stress response protein, and the pleiotropic phenotypes of SIOD are at least partly due to defects in genome maintenance during DNA replication.
Journal ArticleDOI
Sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair
TL;DR: An RNAi screen to identify genes that when silenced cause synthetic lethality with the PARP inhibitor AZD2281 identified the deubiquitylating enzyme USP11 as a component of the HR double-strand break repair pathway.
Journal ArticleDOI
DDB1 maintains genome integrity through regulation of Cdt1
TL;DR: DDB1 prevents DNA lesions from accumulating in replicating human cells, in part by regulating Cdt1 degradation, which is crucial for preventing genome instability.