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Yuchen Jiao
Researcher at Peking Union Medical College
Publications - 112
Citations - 16013
Yuchen Jiao is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Cancer & ATRX. The author has an hindex of 41, co-authored 97 publications receiving 13305 citations. Previous affiliations of Yuchen Jiao include Duke University & Johns Hopkins University.
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
Daxx/atrx, men1, and mtor pathway genes are frequently altered in pancreatic neuroendocrine tumors
Yuchen Jiao,Chanjuan Shi,Barish H. Edil,Roeland F. de Wilde,David S. Klimstra,Anirban Maitra,Richard D. Schulick,Laura H. Tang,Christopher L. Wolfgang,Michael A. Choti,Victor E. Velculescu,Luis A. Diaz,Bert Vogelstein,Kenneth W. Kinzler,Ralph H. Hruban,Nickolas Papadopoulos +15 more
TL;DR: Clinically, mutations in the MEN1 and DAXX/ATRX genes were associated with better prognosis and a finding that could potentially be used to stratify patients for treatment with mTOR inhibitors was found.
Journal ArticleDOI
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,Gary L. Gallia,Beppino C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,Ralph H. Hruban,George I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.K. Ahmed Rasheed,Gregory J. Riggins,Thomas A. Rosenquist,Mark Schiffman,Ie Ming Shih,Dan Theodorescu,Michael Torbenson,Victor E. Velculescu,Tian Li Wang,Nicolas Wentzensen,Laura D. Wood,Ming Zhang,Roger E. McLendon,Darell D. Bigner,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Hai Yan +36 more
TL;DR: TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
Altered Telomeres in Tumors with ATRX and DAXX Mutations
Christopher M. Heaphy,Roeland F. de Wilde,Yuchen Jiao,Alison P. Klein,Barish H. Edil,Chanjuan Shi,Chetan Bettegowda,Fausto J. Rodriguez,Charles G. Eberhart,Sachidanand Hebbar,G. Johan A. Offerhaus,Roger E. McLendon,B.K. Ahmed Rasheed,Yiping He,Hai Yan,Darell D. Bigner,Sueli Mieko Oba-Shinjo,Suely Kazue Nagahashi Marie,Gregory J. Riggins,Kenneth W. Kinzler,Bert Vogelstein,Ralph H. Hruban,Anirban Maitra,Nickolas Papadopoulos,Alan K. Meeker +24 more
TL;DR: The data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes, which are common in human pancreatic neuroendocrine tumors.
Journal ArticleDOI
Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Hai Yan,Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,G.L. Gallia,B.C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,R.H. Hruban,G.I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.A. Rasheed,Gregory J. Riggins,T.A. Rosenquist,M. Schiffman,IeM Shih,Dan Theodorescu,M.S. Torbenson,Victor E. Velculescu,Tian Li Wang,N. Wentzensen,Laura D. Wood,Ming Zhang,Patrick Healy,Rui Yang,Bill H. Diplas,Zhaohui Wang,Paula K. Greer,Huishan Zhu,Catherine Y. Wang,Austin B. Carpenter,James E. Herndon,Roger E. McLendon,Kenneth W. Kinzler,Bert Vogelstein,N. Papadopoulos,Darell D. Bigner +45 more
TL;DR: TERT and ATRX mutations suggest that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.