Saurav De

TL;DR: It is shown that loss of ATRX protein and mutations in the ATRRX gene are hallmarks of ALT–immortalized cell lines, and these attributes will facilitate the diagnosis and treatment ofALT positive human cancers.

TL;DR: RTEL1 is implicates in the etiology of DC/HH and immunodeficiency and identifies the first known homozygous autosomal recessive disease-associated mutation in RTEL1, a helicase with critical telomeric functions in two unrelated families of Ashkenazi Jewish ancestry.

TL;DR: It is shown that transient, selective inhibition of analog-sensitive (AS) Cdk2 after exposure to ionizing radiation (IR) enhances cell-killing and uncovers both a non-redundant requirement for Cdk 2 activity in response to DNA damage and a specific target of Cdk1 within the DNA repair machinery.

TL;DR: It is concluded that the oncogenic potential of double-strand breaks resulting from NHEJ deficiency is highly restricted by nonapoptotic functions of p53, suggesting that the particular facets of the DNA damage response required for tumor suppression are dictated by the proliferative status of the tumor-initiating cell.

TL;DR: The findings support the idea that the essential functions of the Mre11 complex are associated with DNA replication and further suggest that homologous recombination is not essential in nondividing cells.