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Craig A. Strathdee
Researcher at Broad Institute
Publications - 54
Citations - 3864
Craig A. Strathdee is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene & Fanconi anemia, complementation group C. The author has an hindex of 28, co-authored 49 publications receiving 3570 citations. Previous affiliations of Craig A. Strathdee include University of Western Ontario & Amgen.
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Cloning of cDNAs for Fanconi's anaemia by functional complementation.
TL;DR: A functional complementation method is used to clone complementary DNAs that correct the defect of group C cells and represent a new gene involved in the cellular response to DNA damage in Fanconi's anaemia.
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Genetic and transcriptional evolution alters cancer cell line drug response
Uri Ben-David,Benjamin A. Siranosian,Gavin Ha,Gavin Ha,Helen Tang,Yaara Oren,Yaara Oren,Kunihiko Hinohara,Kunihiko Hinohara,Craig A. Strathdee,Joshua M. Dempster,Nicholas J. Lyons,Robert Burns,Anwesha Nag,Guillaume Kugener,Beth A. Cimini,Peter Tsvetkov,Yosef E. Maruvka,Ryan O’Rourke,Ryan O’Rourke,Anthony J. Garrity,Andrew A. Tubelli,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Aviad Tsherniak,Francisca Vazquez,Bang Wong,Chet Birger,Mahmoud Ghandi,Aaron R. Thorner,Joshua A. Bittker,Matthew Meyerson,Matthew Meyerson,Gad Getz,Gad Getz,Rameen Beroukhim,Todd R. Golub +36 more
TL;DR: The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.
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Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9.
TL;DR: Results suggest that mutations in at least four different genes lead to FA, a degree of genetic heterogeneity comparable to that of other DNA repair disorders.
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Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of the Pasteurella haemolytica leukotoxin determinant.
TL;DR: It is hypothesized that the leukotoxin and hemolysin determinants share a common evolutionary history and are prototypes for a widely disseminated family of virulence factors, the RTX cytotoxins.
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Nucleotide sequence of the leukotoxin genes of Pasteurella haemolytica A1.
TL;DR: Results suggested that the leukotoxin genes of P. haemolytica A1 and the E. coli alpha-hemolysin genes may have evolved from a common ancestor and that the two toxins may share similar activities or functional domains or both.