Craig Mizzoni

TL;DR: A tunable 3D bioengineered brain tissue platform is presented by integrating microenvironmental cues of native brain-derived ECMs and live imaging to systematically evaluate patient-derived brain tumor responses to examine the interplay between cells and the ECM.

TL;DR: It is demonstrated that mitochondria play a fundamental role in maintaining bioenergetic homeostasis of both OXPHOS-competent and OX PHOS-defective cells, with Ca2+ regulation of αKGDH activity playing a pivotal role.

TL;DR: An experimental system based on 3D scaffold-based cortical neuron cultures in which the genetically encoded calcium indicator GCaMP6f is expressed to record neuronal activity at the millimeter-scale is presented to illustrate the applicability of this 3D experimental system for the study of brain network development, function, and disruption in a biomimetic microenvironment.

TL;DR: Evidence is provided that the 3D brain‐like culture system mimicked many aspects of in vivo responses to CCI, providing evidence that the model can be used to study the molecular, cellular, and functional sequelae of TBI, opening up new possibilities for discovery of therapeutics.

TL;DR: An experimental system based on 3D scaffold-based cortical neuron cultures in which the genetically encoded calcium indicator GCaMP6f is expressed to record neuronal activity at the millimeter-scale is presented to illustrate the applicability of this 3D experimental system for the study of brain network development, function, and disruption in a biomimetic microenvironment.