M
Michael J. Whalen
Researcher at Harvard University
Publications - 183
Citations - 7122
Michael J. Whalen is an academic researcher from Harvard University. The author has contributed to research in topics: Traumatic brain injury & Medicine. The author has an hindex of 44, co-authored 158 publications receiving 5984 citations. Previous affiliations of Michael J. Whalen include Columbia University & Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift.
TL;DR: A new paradigm to study innate immune cells following TBI is proposed that moves away from the existing M1/M2 classification of activation states toward a stimulus- and disease-specific understanding of polarization state based on transcriptomic and proteomic profiling.
Journal ArticleDOI
Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
Zerong You,Sean I Savitz,Sean I Savitz,Jinsheng Yang,Alexei Degterev,Junying Yuan,Gregory D. Cuny,Michael A. Moskowitz,Michael J. Whalen +8 more
TL;DR: The data suggest that necroptosis plays a significant role in the pathogenesis of cell death and functional outcome after TBI and that ne crostatin-1 may have therapeutic potential for patients with TBI.
Journal ArticleDOI
Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside.
Patrick M. Kochanek,Robert S. B. Clark,Randall A. Ruppel,P. David Adelson,Michael J. Bell,Michael J. Whalen,Courtney L. Robertson,Margaret A. Satchell,Neal A. Seidberg,Donald W. Marion,Larry W. Jenkins +10 more
TL;DR: A constellation of mediators of secondary damage, endogenous neuroprotection, repair, and regeneration are set into motion in the brain after severe traumatic injury.
Journal ArticleDOI
Cell-cell signaling in the neurovascular unit.
Josephine Lok,Punkaj Gupta,Shuzhen Guo,Woo Jean Kim,Michael J. Whalen,Klaus van Leyen,Eng H. Lo +6 more
TL;DR: Four examples of neurovascular coupling linking blood flow to brain activity; cellular communications that evoke the blood–brain barrier phenotype; parallel systems that underlie both neurogenesis and angiogenesis in the CNS; and the potential exchange of trophic factors that may link neuronal, glial and vascular homeostasis are surveyed.
Journal ArticleDOI
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.
Michael J. Bell,Patrick M. Kochanek,Lesley Doughty,Joseph A. Carcillo,P. David Adelson,Robert S. B. Clark,S. R. Wisniewski,Michael J. Whalen,Steven T. DeKosky +8 more
TL;DR: It is demonstrated that IL-6 is increased after TBI in children to levels similar to those reported in adults and is the first to show thatIL-10 is increased in CSF of humans afterTBI.