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Craig P. Webb
Researcher at Van Andel Institute
Publications - 60
Citations - 4443
Craig P. Webb is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 29, co-authored 60 publications receiving 4276 citations.
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Journal ArticleDOI
Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
Nicholas S. Duesbery,Craig P. Webb,Stephen H. Leppla,Valery M. Gordon,Kurt Klimpel,Terry D. Copeland,Natalie G. Ahn,M Oskarsson,Kenji Fukasawa,Ken D. Paull,George F. Vande Woude +10 more
TL;DR: It is shown that LF is a protease that cleaves the amino terminus of mitogen-activated protein kinase kinases 1 and 2 and that this cleavage inactivates MAPKK1 and inhibits the MAPK signal transduction pathway.
Journal ArticleDOI
Activating mutations for the Met tyrosine kinase receptor in human cancer
Michael Jeffers,Laura S. Schmidt,Noboru Nakaigawa,Craig P. Webb,Gregor Weirich,Takeshi Kishida,Berton Zbar,George F. Vande Woude +7 more
TL;DR: The results demonstrate that the Met mutants originally identified in human papillary renal carcinoma are oncogenic and thus are likely to play a determinant role in this disease, and raise the possibility that activating Met mutations also may contribute to other human malignancies.
Journal ArticleDOI
Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium
Frank Dieterle,Frank D. Sistare,Federico Goodsaid,Marisa Papaluca,Josef S Ozer,Josef S Ozer,Craig P. Webb,William Baer,Anthony J. Senagore,Matthew J. Schipper,Jacky Vonderscher,Stefan Sultana,David Gerhold,Jonathan A. Phillips,Gerard Maurer,Kevin Carl,David Laurie,Ernie Harpur,Manisha Sonee,Daniela Ennulat,Dan Holder,Dina Andrews-Cleavenger,Yi Zhong Gu,Karol L. Thompson,Peter L. Goering,Jean Marc Vidal,Eric Abadie,Romaldas Mačiulaitis,David Jacobson-Kram,Albert F. Defelice,Elizabeth Hausner,Melanie Blank,Aliza Thompson,Patricia Harlow,Douglas C. Throckmorton,Shen Xiao,Nancy Xu,William Taylor,Spiros Vamvakas,Bruno Flamion,Beatriz Silva Lima,Peter Kasper,Markku Pasanen,Markku Pasanen,Krishna Prasad,Sean P. Troth,Denise Bounous,Denise Robinson-Gravatt,Graham Betton,Myrtle Davis,Jackie Akunda,James Eric McDuffie,Laura Suter,Leslie A. Obert,Magalie Guffroy,Mark Pinches,Supriya Jayadev,Eric A.G. Blomme,Sven A. Beushausen,Valérie G. Barlow,Nathaniel Collins,Nathaniel Collins,Jeff Waring,David Honor,Sandra Snook,Jinhe Lee,Phil Rossi,Elizabeth G. Walker,William B. Mattes +68 more
TL;DR: This was a pilot process, and the experience gained will both facilitate better understanding of how the qualification process will probably evolve and clarify the minimal requirements necessary to evaluate the performance of biomarkers of organ injury within specific contexts.
Journal ArticleDOI
The mutationally activated Met receptor mediates motility and metastasis
Michael Jeffers,M Fiscella,Craig P. Webb,Miriam R. Anver,Shahriar Koochekpour,George F. Vande Woude +5 more
TL;DR: It is found that mutant Met induces the motility of Madin-Darby canine kidney cells in vitro and experimental metastasis of NIH 3T3 cells in vivo, and that the Ras-Raf-MEK-ERK signaling pathway, which has been implicated previously in cellular motility and metastasis, is constitutively activated by the Met mutants.
Journal ArticleDOI
Signaling pathways in Ras-mediated tumorigenicity and metastasis
TL;DR: Results show that the metastatic properties of the Ras effector domain mutants segregate, and that, whereas Ras-mediated tumorigenicity can arise independently of ERK1/2 activation, experimental metastasis appears to require constitutive activation of the ERK 1/2 pathway.