J
Jacky Vonderscher
Researcher at Novartis
Publications - 67
Citations - 2574
Jacky Vonderscher is an academic researcher from Novartis. The author has contributed to research in topics: Renal function & Drug development. The author has an hindex of 19, co-authored 62 publications receiving 2392 citations. Previous affiliations of Jacky Vonderscher include French Institute of Health and Medical Research & Hoffmann-La Roche.
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Journal ArticleDOI
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
Vishal S. Vaidya,Josef S Ozer,Josef S Ozer,Frank Dieterle,Fitz B. Collings,Victoria Ramírez,Sean P. Troth,Nagaraja Muniappa,Douglas Thudium,David Gerhold,Daniel J. Holder,Norma A. Bobadilla,Estelle Marrer,Elias Perentes,André Cordier,Jacky Vonderscher,Gerard Maurer,Peter L. Goering,Frank D. Sistare,Joseph V. Bonventre +19 more
TL;DR: Urinary Kim-1 measurements may facilitate sensitive, specific and accurate prediction of human nephrotoxicity in preclinical drug screens, which should enable early identification and elimination of compounds that are potentiallyNephrotoxic.
Journal ArticleDOI
Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium
Frank Dieterle,Frank D. Sistare,Federico Goodsaid,Marisa Papaluca,Josef S Ozer,Josef S Ozer,Craig P. Webb,William Baer,Anthony J. Senagore,Matthew J. Schipper,Jacky Vonderscher,Stefan Sultana,David Gerhold,Jonathan A. Phillips,Gerard Maurer,Kevin Carl,David Laurie,Ernie Harpur,Manisha Sonee,Daniela Ennulat,Dan Holder,Dina Andrews-Cleavenger,Yi Zhong Gu,Karol L. Thompson,Peter L. Goering,Jean Marc Vidal,Eric Abadie,Romaldas Mačiulaitis,David Jacobson-Kram,Albert F. Defelice,Elizabeth Hausner,Melanie Blank,Aliza Thompson,Patricia Harlow,Douglas C. Throckmorton,Shen Xiao,Nancy Xu,William Taylor,Spiros Vamvakas,Bruno Flamion,Beatriz Silva Lima,Peter Kasper,Markku Pasanen,Markku Pasanen,Krishna Prasad,Sean P. Troth,Denise Bounous,Denise Robinson-Gravatt,Graham Betton,Myrtle Davis,Jackie Akunda,James Eric McDuffie,Laura Suter,Leslie A. Obert,Magalie Guffroy,Mark Pinches,Supriya Jayadev,Eric A.G. Blomme,Sven A. Beushausen,Valérie G. Barlow,Nathaniel Collins,Nathaniel Collins,Jeff Waring,David Honor,Sandra Snook,Jinhe Lee,Phil Rossi,Elizabeth G. Walker,William B. Mattes +68 more
TL;DR: This was a pilot process, and the experience gained will both facilitate better understanding of how the qualification process will probably evolve and clarify the minimal requirements necessary to evaluate the performance of biomarkers of organ injury within specific contexts.
Journal ArticleDOI
Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury
Frank Dieterle,Elias Perentes,André Cordier,Daniel Robert Roth,P. F. Verdes,Olivier Grenet,Serafino Pantano,Pierre Moulin,Daniel Wahl,Andreas Mahl,Peter End,Frank Staedtler,Francois Legay,Kevin Carl,David Laurie,Salah-Dine Chibout,Jacky Vonderscher,Gerard Maurer +17 more
TL;DR: Gene and protein expression analysis, in-situ hybridization and immunohistochemistry provide mechanistic evidence to support the use of four previously described nephrotoxicity markers for detecting kidney injury to guide regulatory decision making in drug development.
Journal ArticleDOI
A Panel of Urinary Biomarkers to Monitor Reversibility of Renal Injury and a Serum Marker With Improved Potential to Assess Renal Function
Josef S Ozer,Frank Dieterle,Sean P. Troth,Elias Perentes,André Cordier,P. F. Verdes,Frank Staedtler,Andreas Mahl,Olivier Grenet,Daniel Robert Roth,Daniel Wahl,Francois Legay,Daniel J. Holder,Zoltan Erdos,Katerina Vlasakova,Hong Jin,Yan Yu,Nagaraja Muniappa,Tom Forest,Holly K Clouse,Spencer Reynolds,Wendy J. Bailey,Douglas Thudium,Michael J Topper,Thomas R. Skopek,Joseph F. Sina,Warren E. Glaab,Jacky Vonderscher,Jacky Vonderscher,Gerard Maurer,Salah-Dine Chibout,Frank D. Sistare,David Gerhold +32 more
TL;DR: The authors' assay for serum cystatin C is more sensitive and specific than serum creatinine (SCr) or blood urea nitrogen (BUN) in monitoring generalized renal function after exposure of rats to eight nephrotoxicants and two hepatotoxicants.
Journal ArticleDOI
Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression.
Florence Allantaz,Donavan T. Cheng,Tobias Bergauer,Palanikumar Ravindran,Michel F. Rossier,Martin Ebeling,Laura Badi,Bernhard Reis,Hans Bitter,Matilde D'Asaro,Alberto Chiappe,Sriram Sridhar,Gonzalo Durán Pacheco,Michael E. Burczynski,Denis F. Hochstrasser,Jacky Vonderscher,Thomas Matthes +16 more
TL;DR: The miRNA and mRNA expression profiles reported in this study form a comprehensive transcriptome database of various human blood cells and serve as a valuable resource for elucidating the role of miRNA mediated regulation in the establishment of immune cell identity.