C
Cressida A. Madigan
Researcher at University of California, Los Angeles
Publications - 12
Citations - 1019
Cressida A. Madigan is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Mycobacterium leprae & Innate immune system. The author has an hindex of 8, co-authored 11 publications receiving 898 citations. Previous affiliations of Cressida A. Madigan include University of Washington & University of Michigan.
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Journal ArticleDOI
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
Ari B. Molofsky,Brenda G. Byrne,Natalie N. Whitfield,Cressida A. Madigan,Etsu T. Fuse,Kazuhiro Tateda,Michele S. Swanson +6 more
TL;DR: In this paper, the authors reported that mouse macrophages restricted Legionella pneumophila replication and initiated a proinfl ammatory program of cell death when fl agellin contaminated their cytosol.
Journal ArticleDOI
A Comparative Lipidomics Platform for Chemotaxonomic Analysis of Mycobacterium tuberculosis
Emilie Layre,Lindsay Sweet,Sunhee Hong,Cressida A. Madigan,Danielle Desjardins,David C. Young,Tan-Yun Cheng,John W. Annand,Keunpyo Kim,Isdore Chola Shamputa,Matthew J. McConnell,C. Anthony Debono,Samuel M. Behar,Adriaan J. Minnaard,Megan Murray,Clifton E. Barry,Isamu Matsunaga,D. Branch Moody +17 more
TL;DR: By rapidly regenerating lipidomic datasets during biological processes, comparative lipidomics provides statistically valid, organism-wide comparisons that broadly assess lipid changes during infection or among clinical strains of mycobacteria.
Journal ArticleDOI
A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy
Cressida A. Madigan,Cressida A. Madigan,C.J. Cambier,Kindra M. Kelly-Scumpia,Philip O. Scumpia,Tan-Yun Cheng,Joseph Zailaa,Barry R. Bloom,D. Branch Moody,Stephen T. Smale,Alvaro Sagasti,Robert L. Modlin,Lalita Ramakrishnan +12 more
TL;DR: These findings implicate the response of innate macrophages to M. leprae PGL-1 in initiating nerve damage in leprosy, which is unique among mycobacterial diseases in producing peripheral neuropathy.
Journal ArticleDOI
Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system
Shouxiong Huang,Tan-Yun Cheng,David C. Young,Emilie Layre,Cressida A. Madigan,John Shires,Vincenzo Cerundolo,John D. Altman,D. Branch Moody +8 more
TL;DR: It is found that ligands selectively associated with CD1b lacked the hydrophilic head group that is generally needed for antigen recognition but interferes with scaffold function, and the scaffolds as deoxyceramides and diacylglycerols directly demonstrate a function in augmenting presentation of a small glycolipid antigen to T cells.
Journal ArticleDOI
Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis
Cressida A. Madigan,Tan-Yun Cheng,Emilie Layre,David C. Young,Matthew McConnell,C. Anthony Debono,Jeffrey P. Murry,Jun-Rong Wei,Clifton E. Barry,G. Marcela Rodriguez,Isamu Matsunaga,Eric J. Rubin,D. Branch Moody +12 more
TL;DR: Lipidomics is an efficient discovery tool that informs genetic relationships, leading to a revised general model for the biosynthesis of these virulence-conferring siderophores in Mycobacterium tuberculosis, and shows that deoxymycobactins are actively regulated during iron starvation.