C
Cristiane H. Squarize
Researcher at University of Michigan
Publications - 83
Citations - 3224
Cristiane H. Squarize is an academic researcher from University of Michigan. The author has contributed to research in topics: Epigenetics & Cancer stem cell. The author has an hindex of 26, co-authored 67 publications receiving 2602 citations. Previous affiliations of Cristiane H. Squarize include University of São Paulo & National Institutes of Health.
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Journal ArticleDOI
mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
Rogerio M. Castilho,Cristiane H. Squarize,Lewis A. Chodosh,Bart O. Williams,J. Silvio Gutkind +4 more
TL;DR: Whereas activation of beta-catenin contributes to tumor growth, epithelial stem cells may be endowed with a protective mechanism that results in cell senescence upon the persistent stimulation of proliferative pathways that activate mTOR, ultimately suppressing tumor formation.
Journal ArticleDOI
Dysregulated molecular networks in head and neck carcinogenesis
Alfredo A. Molinolo,Panomwat Amornphimoltham,Cristiane H. Squarize,Rogerio M. Castilho,Vyomesh Patel,J. Silvio Gutkind +5 more
TL;DR: The emerging information on how the use of modern technologies and the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFkappaB, Stat, Wnt/beta-catenin, TGF-beta, and PI3K-AKT-mTOR signaling pathways can help elucidate the molecular mechanisms underlying HNSCC progression is discussed.
Journal ArticleDOI
Molecular Cross-Talk between the NFκB and STAT3 Signaling Pathways in Head and Neck Squamous Cell Carcinoma
Cristiane H. Squarize,Cristiane H. Squarize,Rogerio M. Castilho,Virote Sriuranpong,Décio dos Santos Pinto,Jorge S. Gutkind +5 more
TL;DR: These findings demonstrate a cross-talk between the NFkappaB and the STAT3 signaling systems, and support the emerging notion that HNSCC results from the aberrant activity of a signaling network.
Journal ArticleDOI
Accelerated wound healing by mTOR activation in genetically defined mouse models.
Cristiane H. Squarize,Cristiane H. Squarize,Rogerio M. Castilho,Rogerio M. Castilho,Thomas H. Bugge,J. Silvio Gutkind +5 more
TL;DR: The findings indicate that the transient pharmacologic activation of the PI3K-Akt-mTOR signaling axis may represent a novel clinical intervention strategy to accelerate the healing of debilitating and life-threatening wounds.
Journal ArticleDOI
Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.
TL;DR: The understanding and characterization of epigenetic modifications associated with head and neck carcinogenesis, and the prospective identification of epigenetics markers associated with CSCs, hold the promise for novel therapeutic strategies to fight tumors.