C
Cristina Corbetta
Publications - 8
Citations - 349
Cristina Corbetta is an academic researcher. The author has contributed to research in topics: Immunotherapy & Glioma. The author has an hindex of 6, co-authored 7 publications receiving 278 citations.
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Journal ArticleDOI
Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy
S. Pellegatta,Barbara Savoldo,Natalia Di Ianni,Cristina Corbetta,Yuhui Chen,Monica Patanè,Chuang Sun,Bianca Pollo,Soldano Ferrone,Francesco DiMeco,Gaetano Finocchiaro,Gianpietro Dotti +11 more
TL;DR: Overall, the constitutive and TNFα-inducible expression of CSPG4 in GBM may greatly reduce the risk of tumor cell escape observed when targeted antigens are heterogeneously expressed on tumor cells.
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Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
Serena Pellegatta,Lorella Valletta,Cristina Corbetta,Monica Patanè,Ileana Zucca,Federico Riccardi Sirtori,Maria Grazia Bruzzone,Gianpaolo Fogliatto,Antonella Isacchi,Bianca Pollo,Gaetano Finocchiaro +10 more
TL;DR: The results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations and led to intratumoral up-regulation of IFN-γ, granzyme-b and perforin-1 and down- regulation of TGF-β2 and IL-10.
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Survival gain in glioblastoma patients treated with dendritic cell immunotherapy is associated with increased NK but not CD8+ T cell activation in the presence of adjuvant temozolomide.
Serena Pellegatta,Marica Eoli,Valeria Cuccarini,Elena Anghileri,Bianca Pollo,Sara Pessina,Simona Frigerio,Maura Servida,Lucia Cuppini,Carlo Antozzi,Stefania Cuzzubbo,Cristina Corbetta,Rosina Paterra,Francesco Acerbi,Paolo Ferroli,Francesco DiMeco,Laura Fariselli,Eugenio Parati,Maria Grazia Bruzzone,Gaetano Finocchiaro +19 more
TL;DR: The negative effect of TMZ on the formation of T cell-associated antitumor memory deserves consideration in future clinical trials including immunotherapy.
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Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma.
Cristina Corbetta,Natalia Di Ianni,Maria Grazia Bruzzone,Monica Patanè,Bianca Pollo,Gabriele Cantini,Manuela Cominelli,Ileana Zucca,Federica Pisati,Pietro Luigi Poliani,Gaetano Finocchiaro,Serena Pellegatta +11 more
TL;DR: GLAST has a novel role in GBM that appears to have crucial relevance in glutamate trafficking and may thus be a new therapeutic target.
Journal ArticleDOI
Expansion of effector and memory T cells is associated with increased survival in recurrent glioblastomas treated with dendritic cell immunotherapy.
Marica Eoli,Cristina Corbetta,Elena Anghileri,Natalia Di Ianni,Micaela Milani,Valeria Cuccarini,Silvia Musio,Rosina Paterra,Simona Frigerio,Sara Nava,Daniela Lisini,Sara Pessina,Luisa Maddaloni,Raffaella Lombardi,Maria Tardini,Paolo Ferroli,Francesco DiMeco,Maria Grazia Bruzzone,Carlo Antozzi,Bianca Pollo,Gaetano Finocchiaro,Serena Pellegatta +21 more
TL;DR: TT preconditioning of the vaccine site and lack of TMZ could contribute to the efficacy of DC immunotherapy by inducing an effector response, memory, and helper T-cell generation.