M
Monica Patanè
Researcher at German Cancer Research Center
Publications - 31
Citations - 614
Monica Patanè is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 23 publications receiving 465 citations.
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Journal ArticleDOI
Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy
S. Pellegatta,Barbara Savoldo,Natalia Di Ianni,Cristina Corbetta,Yuhui Chen,Monica Patanè,Chuang Sun,Bianca Pollo,Soldano Ferrone,Francesco DiMeco,Gaetano Finocchiaro,Gianpietro Dotti +11 more
TL;DR: Overall, the constitutive and TNFα-inducible expression of CSPG4 in GBM may greatly reduce the risk of tumor cell escape observed when targeted antigens are heterogeneously expressed on tumor cells.
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The MET oncogene is a functional marker of a glioblastoma stem cell subtype
Francesca De Bacco,Elena Casanova,Enzo Medico,Serena Pellegatta,Francesca Orzan,Raffaella Albano,Paolo Luraghi,Gigliola Reato,Antonio D'Ambrosio,Paola Porrati,Monica Patanè,Emanuela Maderna,Bianca Pollo,Paolo M. Comoglio,Gaetano Finocchiaro,Carla Boccaccio +15 more
TL;DR: It is found that expression of the MET oncogene was associated with neurospheres expressing the gene signature of mesenchymal and proneural subtypes of glioblastoma and is a candidate target for identification and therapy of a subset of glooblastomas.
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Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
Serena Pellegatta,Lorella Valletta,Cristina Corbetta,Monica Patanè,Ileana Zucca,Federico Riccardi Sirtori,Maria Grazia Bruzzone,Gianpaolo Fogliatto,Antonella Isacchi,Bianca Pollo,Gaetano Finocchiaro +10 more
TL;DR: The results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations and led to intratumoral up-regulation of IFN-γ, granzyme-b and perforin-1 and down- regulation of TGF-β2 and IL-10.
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B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.
Dean Nehama,Natalia Di Ianni,Silvia Musio,Hongwei Du,Monica Patanè,Bianca Pollo,Gaetano Finocchiaro,James J. H. Park,Denise E. Dunn,Drake S. Edwards,Jeffrey S. Damrauer,Hannah Hudson,Scott R. Floyd,Soldano Ferrone,Barbara Savoldo,Serena Pellegatta,Gianpietro Dotti +16 more
TL;DR: It is demonstrated that B7-H3 is highly expressed in GBM specimens and neurospheres that contain putative cancer stem cells, and that B 7- H3-redirected CAR-T cells can effectively control tumor growth.
Journal ArticleDOI
First ex vivo validation of a radioguided surgery technique with β-radiation
E. Solfaroli Camillocci,Marco Schiariti,V. Bocci,A. Carollo,G. Chiodi,Marzia Colandrea,Francesco Collamati,Marta Cremonesi,Raffaella Donnarumma,Mahila Ferrari,Paolo Ferroli,F. Ghielmetti,Chiara Maria Grana,C. Mancini Terracciano,M. Marafini,S. Morganti,Monica Patanè,Guido Pedroli,Bianca Pollo,L. Recchia,A. Russomando,M. Toppi,Giacomo Traini,R. Faccini +23 more
TL;DR: This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct.