Cristina Romero-López

TL;DR: This study represents the first identification, characterization, and functional validation of a human miRNA promoter in stem cells and opens up new avenues to further investigate the upstream transcriptional regulation of the miR302-367 cluster.

TL;DR: The present data firmly suggest the existence of a higher-order structure that may mediate a protein-independent circularization of the HCV genome and the 5'-3' end bridge may have a role in viral translation modulation and in the switch from protein synthesis to RNA replication.

TL;DR: On the 20th anniversary of ribozyme discovery the main features of the different natural catalytic RNAs are summarized and progress towards developing strategies to ensure an efficient ribo enzyme-based technology is described.

TL;DR: Evidence is provided that the enhancement of HCV IRES-dependent translation mediated by the 3′UTR is negatively controlled by the CRE region in the human hepatoma cell lines Huh-7 and Hep-G2 in a time-dependent manner, supporting the existence of a functional high order structure in the HCV genome that involves two evolutionarily conserved RNA elements.

TL;DR: The preservation of this RNA–RNA interacting network, and the maintenance of the proper balance between different contacts, may play a crucial role in the switch between different steps of the HCV cycle.