G
Gustavo J. Melen
Researcher at Autonomous University of Madrid
Publications - 41
Citations - 1474
Gustavo J. Melen is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Mesenchymal stem cell & Oncolytic virus. The author has an hindex of 20, co-authored 41 publications receiving 1293 citations. Previous affiliations of Gustavo J. Melen include University of Granada & Menéndez Pelayo International University.
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Journal ArticleDOI
Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter.
Alicia Barroso-delJesus,Cristina Romero-López,Gema Lucena-Aguilar,Gema Lucena-Aguilar,Gustavo J. Melen,Laura Sánchez,Gertrudis Ligero,Alfredo Berzal-Herranz,Pablo Menendez +8 more
TL;DR: This study represents the first identification, characterization, and functional validation of a human miRNA promoter in stem cells and opens up new avenues to further investigate the upstream transcriptional regulation of the miR302-367 cluster.
Journal ArticleDOI
Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene
Pablo Menendez,Purificación Catalina,Rene Rodriguez,Gustavo J. Melen,Clara Bueno,Mar Arriero,Félix García-Sánchez,Alvaro Lassaletta,Ramón García-Sanz,Javier García-Castro,Javier García-Castro +10 more
TL;DR: The absence of monoclonal rearrangements in MLL-AF4+ BM-MSCs precludes the possibility of cellular plasticity or de-differentiation of B-ALL blasts and suggests that MLL -AF4 might arise in a population of prehematopoietic precursors.
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Threshold responses to morphogen gradients by zero‐order ultrasensitivity
TL;DR: It is proposed that a reversible loop of Yan phosphorylation implements a zero‐order ultrasensitivity‐like threshold mechanism, with the capacity to form sharp thresholds that are independent of the level of Yan.
Journal ArticleDOI
Coordination between transcription and pre-mRNA processing.
Paula Cramer,Anabella Srebrow,Sebastian Kadener,Santiago E. Werbajh,M. de la Mata,Gustavo J. Melen,Guadalupe Nogués,Alberto R. Kornblihtt +7 more
TL;DR: The presence and degree of phosphorylation of the carboxy‐terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex.
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Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-beta and IGF-II.
Rosa Montes,Gertrudis Ligero,Laura Sánchez,Purificación Catalina,Teresa de la Cueva,Ana Nieto,Gustavo J. Melen,Ruth Rubio,Javier García-Castro,Clara Bueno,Pablo Menendez +10 more
TL;DR: In this article, a paracrine regulation was proposed in human embryonic stem cells (hESCs) grown in MEF-conditioned media (MEF-CM), where hESCs spontaneously differentiate into autologous fibroblast-like cells to maintain culture homeostasis by producing TGF-beta and insulin-like growth factor-II (IGF-II) in response to basic fibroblasts growth factor (bFGF).