C
Cristina Romero-López
Researcher at Spanish National Research Council
Publications - 53
Citations - 1224
Cristina Romero-López is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: RNA & Internal ribosome entry site. The author has an hindex of 17, co-authored 50 publications receiving 1125 citations.
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Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter.
Alicia Barroso-delJesus,Cristina Romero-López,Gema Lucena-Aguilar,Gema Lucena-Aguilar,Gustavo J. Melen,Laura Sánchez,Gertrudis Ligero,Alfredo Berzal-Herranz,Pablo Menendez +8 more
TL;DR: This study represents the first identification, characterization, and functional validation of a human miRNA promoter in stem cells and opens up new avenues to further investigate the upstream transcriptional regulation of the miR302-367 cluster.
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A long-range RNA–RNA interaction between the 5′ and 3′ ends of the HCV genome
TL;DR: The present data firmly suggest the existence of a higher-order structure that may mediate a protein-independent circularization of the HCV genome and the 5'-3' end bridge may have a role in viral translation modulation and in the switch from protein synthesis to RNA replication.
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Ribozymes: recent advances in the development of RNA tools.
TL;DR: On the 20th anniversary of ribozyme discovery the main features of the different natural catalytic RNAs are summarized and progress towards developing strategies to ensure an efficient ribo enzyme-based technology is described.
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The functional RNA domain 5BSL3.2 within the NS5B coding sequence influences hepatitis C virus IRES-mediated translation.
TL;DR: Evidence is provided that the enhancement of HCV IRES-dependent translation mediated by the 3′UTR is negatively controlled by the CRE region in the human hepatoma cell lines Huh-7 and Hep-G2 in a time-dependent manner, supporting the existence of a functional high order structure in the HCV genome that involves two evolutionarily conserved RNA elements.
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End-to-end crosstalk within the hepatitis C virus genome mediates the conformational switch of the 3′X-tail region
Cristina Romero-López,Alicia Barroso-delJesus,Ana García-Sacristán,Carlos Briones,Alfredo Berzal-Herranz +4 more
TL;DR: The preservation of this RNA–RNA interacting network, and the maintenance of the proper balance between different contacts, may play a crucial role in the switch between different steps of the HCV cycle.