C
Cyrill Brunner
Researcher at ETH Zurich
Publications - 16
Citations - 146
Cyrill Brunner is an academic researcher from ETH Zurich. The author has contributed to research in topics: Cancer research & Fibroblast growth factor receptor. The author has an hindex of 4, co-authored 12 publications receiving 85 citations. Previous affiliations of Cyrill Brunner include École Polytechnique Fédérale de Lausanne.
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When barriers ignore the “rule-of-five”
Stefanie D. Krämer,Hélène E. Aschmann,Maja Hatibovic,Katharina F. Hermann,Claudia S. Neuhaus,Cyrill Brunner,Sara Belli +6 more
TL;DR: Experimental data with liposomes and molecular dynamics simulations suggest that the formation of intramolecular H-bonds and the possibility to adopt an elongated shape besides the presence of a significant fraction of net neutral species facilitate lipid bilayer permeation.
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De Novo Fragment Design for Drug Discovery and Chemical Biology.
Tiago Rodrigues,Daniel Reker,M. Welin,Michael Caldera,Cyrill Brunner,Gisela Gabernet,Petra Schneider,Björn Walse,Gisbert Schneider +8 more
TL;DR: The study validates computational de novo design as a prime method for generating chemical probes and starting points for drug discovery and identifies additional macromolecular targets of the computationally designed compound and the structurally related marketed drug azosemide.
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A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding.
Sabine Bernegger,Cyrill Brunner,Matej Vizovišek,Marko Fonović,Gaetano Cuciniello,Gaetano Cuciniello,Flavia Giordano,Vesna Stanojlovic,Miroslaw Jarzab,Philip C. Simister,Stephan M. Feller,Gerhard Obermeyer,Gernot Posselt,Boris Turk,Chiara Cabrele,Gisbert Schneider,Silja Wessler +16 more
TL;DR: A novel fluorescence resonance energy transfer (FRET) peptide derived from a gel-based label-free proteomic approach is designed as a valuable substrate for H. pylori HtrA to contribute to the development of novel metal ion-dependent protease inhibitors, which might help to fight bacterial infections.
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Binding Specificities of Nanobody•Membrane Protein Complexes obtained from Chemical Cross-linking and High- Mass MALDI Mass Spectrometry
Martin Kohler,Christoph Neff,Camilo Perez,Cyrill Brunner,Els Pardon,Jan Steyaert,Gisbert Schneider,Kaspar P. Locher,Renato Zenobi +8 more
TL;DR: It is shown how chemical cross-linking combined with high-mass matrix-assisted laser/desorption ionization mass spectrometry can be employed as a fast screening technique to determine binding specificities of intact nanobody•membrane protein complexes.
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Leveraging molecular structure and bioactivity with chemical language models for de novo drug design
Michael Moret,Irene Pachón Angona,Leandro Cotos,Shen Yan,Kenneth Atz,Cyrill Brunner,Martin Baumgartner,Francesca Grisoni,O. Schneider +8 more
TL;DR: In this paper , a collection of virtual molecules was created with a generative chemical language model (CLM) for de novo molecular structure generation by learning from a textual representation of molecules.