D
D. Alan Anthoney
Researcher at St James's University Hospital
Publications - 1
Citations - 271
D. Alan Anthoney is an academic researcher from St James's University Hospital. The author has contributed to research in topics: Cytotoxic T cell & Interferon. The author has an hindex of 1, co-authored 1 publications receiving 187 citations.
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Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade
Adel Samson,Karen Scott,David Taggart,Emma West,Erica B. Wilson,Gerard J. Nuovo,Simon Thomson,Robert Corns,Ryan K. Mathew,Martin Fuller,Timothy Kottke,Jill Thompson,Elizabeth Ilett,Julia V. Cockle,Philip van Hille,Gnanamurthy Sivakumar,Euan S. Polson,Samantha J. Turnbull,Elizabeth S. Appleton,Gemma Migneco,Ailsa Rose,Matthew C. Coffey,D. Beirne,Fiona Collinson,Christy Ralph,D. Alan Anthoney,Chris Twelves,Andrew Furness,Sergio A. Quezada,Heiko Wurdak,Fiona Errington-Mais,Hardev Pandha,Kevin J. Harrington,Peter Selby,Richard G. Vile,Stephen Griffin,Lucy F. Stead,Susan C Short,Alan Melcher +38 more
TL;DR: It is shown, in a window-of-opportunity clinical study, that intravenous infusion of oncolytic human Orthoreovirus leads to infection of tumor cells subsequently resected as part of standard clinical care, both in high-grade glioma and in brain metastases, and increases cytotoxic T cell tumor infiltration relative to patients not treated with virus.