Heiko Wurdak

TL;DR: It is shown, in a window-of-opportunity clinical study, that intravenous infusion of oncolytic human Orthoreovirus leads to infection of tumor cells subsequently resected as part of standard clinical care, both in high-grade glioma and in brain metastases, and increases cytotoxic T cell tumor infiltration relative to patients not treated with virus.

TL;DR: Stauprimide is identified as a chemical tool that primes ESCs for efficient differentiation through a mechanism that affects c-Myc expression, and this study points to an important role for NME2 in ESC self-renewal.

TL;DR: It is shown that bone morphogenic protein (BMP) signaling antagonizes the sensory fate-inducing activity of Wnt/β-catenin, and furthermore, Wnt and BMP act synergistically to suppress differentiation and to maintain NCSC marker expression and multipotency.

TL;DR: Specific inactivation of TGFbeta signaling in neural crest stem cells results in cardiovascular defects and thymic, parathyroid, and craniofacial anomalies in DiGeorge syndrome.

TL;DR: A kinome-wide RNA interference screen is described to identify factors that control the tumorigenicity of BTICs and support a critical role for TRRAP in maintaining a tumorigenic, stem cell-like state.