R
Robert Corns
Researcher at Leeds Teaching Hospitals NHS Trust
Publications - 3
Citations - 283
Robert Corns is an academic researcher from Leeds Teaching Hospitals NHS Trust. The author has contributed to research in topics: Oncolytic virus & Cytotoxic T cell. The author has an hindex of 3, co-authored 3 publications receiving 197 citations. Previous affiliations of Robert Corns include St James's University Hospital.
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Journal ArticleDOI
Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade
Adel Samson,Karen Scott,David Taggart,Emma West,Erica B. Wilson,Gerard J. Nuovo,Simon Thomson,Robert Corns,Ryan K. Mathew,Martin Fuller,Timothy Kottke,Jill Thompson,Elizabeth Ilett,Julia V. Cockle,Philip van Hille,Gnanamurthy Sivakumar,Euan S. Polson,Samantha J. Turnbull,Elizabeth S. Appleton,Gemma Migneco,Ailsa Rose,Matthew C. Coffey,D. Beirne,Fiona Collinson,Christy Ralph,D. Alan Anthoney,Chris Twelves,Andrew Furness,Sergio A. Quezada,Heiko Wurdak,Fiona Errington-Mais,Hardev Pandha,Kevin J. Harrington,Peter Selby,Richard G. Vile,Stephen Griffin,Lucy F. Stead,Susan C Short,Alan Melcher +38 more
TL;DR: It is shown, in a window-of-opportunity clinical study, that intravenous infusion of oncolytic human Orthoreovirus leads to infection of tumor cells subsequently resected as part of standard clinical care, both in high-grade glioma and in brain metastases, and increases cytotoxic T cell tumor infiltration relative to patients not treated with virus.
Journal ArticleDOI
Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas.
Marc Zanello,Marc Zanello,John Goodden,Henry Colle,Michel Wager,Philip C. De Witt Hamer,Anja Smits,Anja Smits,Lorenzo Bello,Matthew C. Tate,Giannantonio Spena,Damien Bresson,Laurent Capelle,Santiago Gil Robles,Silvio Sarubbo,Bertil Rydenhag,Juan Martino,Bernhard Meyer,Denys Fontaine,Nicolas Reyns,Christian Schichor,Philippe Metellus,David Colle,Erik Robert,B. Noens,Peter Barkholt Muller,Marco Rossi,Marco Conti Nibali,Costanza Papagno,Lara Galbarritu,Edurne Ruiz de Gopegui,Franco Chioffi,Carlos Bucheli,Sandro M. Krieg,Maria Wostrack,Natan Yusupov,Victoria Visser,Johannes C. Baaijen,Alexandre Roux,Alexandre Roux,Edouard Dezamis,Edouard Dezamis,Emmanuel Mandonnet,Robert Corns,Hugues Duffau,Johan Pallud,Johan Pallud +46 more
TL;DR: The functional-based resection using intraoperative functional brain mapping allows safe resection of CA and the peripheral hemosiderin rim located within or close to eloquent brain areas.
Journal ArticleDOI
Oncolytic wild-type reovirus infection in brain tumors following intravenous administration in patients.
Adel Jebar,Emma West,Karen Scott,Simon Thomson,Robert Corns,Matthew C. Coffey,Ailsa Rose,Gerard J. Nuovo,Matthew Ryan,Fiona Errington-Mais,Christy Ralph,Chris Twelves,Stephen Griffin,Kevin J. Harrington,Hardev Pandha,Olly Donnely,Peter Selby,Richard G. Vile,Susan C Short,Alan Melcher +19 more
TL;DR: This trial aims to identify whether wild-type reovirus can cross the blood brain barrier and infect brain tumours following intravenous administration.