H
Helai P. Mohammad
Researcher at Johns Hopkins University
Publications - 15
Citations - 2125
Helai P. Mohammad is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 12, co-authored 14 publications receiving 1974 citations. Previous affiliations of Helai P. Mohammad include GlaxoSmithKline & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Joyce E. Ohm,Kelly M. McGarvey,Xiaobing Yu,Linzhao Cheng,Kornel E. Schuebel,Leslie Cope,Helai P. Mohammad,Wei Chen,Vincent C. Daniel,Wayne Yu,David M. Berman,Thomas Jenuwein,Kevin Pruitt,Saul J. Sharkis,D. Neil Watkins,James G. Herman,Stephen B. Baylin +16 more
TL;DR: It is hypothesized that cell chromatin patterns and transient silencing of these important regulatory genes in stem or progenitor cells may leave these genes vulnerable to aberrant DNA hypermethylation and heritable gene silencing during tumor initiation and progression.
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Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.
TL;DR: The data suggest that normal repair of a DNA break can occasionally cause heritable silencing of a CpG island–containing promoter by recruitment of proteins involved in silencing.
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DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
Eriko G. Clements,Helai P. Mohammad,Benjamin Leadem,Hariharan Easwaran,Yi Cai,Leander Van Neste,Stephen B. Baylin +6 more
TL;DR: The findings show that there are genes for which DNMT1 acts as a transcriptional repressor independent from its methyltransferase function and that this repressive function may invoke a role for a scaffolding function of the protein at target genes.
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The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.
Yi Cai,Ernst-Jan Geutjes,K. De Lint,Paul Roepman,L. Bruurs,L. R. Yu,Wei Wang,J. Van Blijswijk,Helai P. Mohammad,I. De Rink,René Bernards,Stephen B. Baylin +11 more
TL;DR: It is found that depletion of CHD4 is synergistic with DNMT inhibition in reducing the viability of colon cancer cells in correlation with reactivation of TSGs, suggesting that their combined inhibition may be beneficial for the treatment of Colon cancer.
Journal ArticleDOI
Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation
Helai P. Mohammad,Yi Cai,Kelly M. McGarvey,Hariharan Easwaran,Leander Van Neste,Joyce E. Ohm,Heather M. O'Hagan,Stephen B. Baylin +7 more
TL;DR: A potential mechanism through assembly of novel repressive complexes, by which the polycomb component of PRC1 can promote the initiation of epigenetic changes involving abnormal DNA hypermethylation of genes frequently silenced in adult cancers is proposed.