D
Da Hye Lee
Researcher at Chungnam National University
Publications - 10
Citations - 604
Da Hye Lee is an academic researcher from Chungnam National University. The author has contributed to research in topics: Hippo signaling pathway & Lung cancer. The author has an hindex of 5, co-authored 9 publications receiving 435 citations. Previous affiliations of Da Hye Lee include KAIST.
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Journal ArticleDOI
YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation
Jongshin Kim,Yoo Hyung Kim,Jaeryung Kim,Do Young Park,Hosung Bae,Da Hye Lee,Kyun Hoo Kim,Seon Pyo Hong,Seung Pil Jang,Yoshiaki Kubota,Young Guen Kwon,Dae-Sik Lim,Gou Young Koh +12 more
TL;DR: Results show that YAP/TAZ plays multifaceted roles for EC behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation and maturation and could be a potential therapeutic target for treating neovascular diseases.
Journal ArticleDOI
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
Da Hye Lee,Jae Oh Park,Tae Shin Kim,Sang Kyum Kim,Tackhoon Kim,Minchul Kim,Gun Soo Park,Jeong-Hwan Kim,Shinji Kuninaka,Eric N. Olson,Hideyuki Saya,Seon-Young Kim,Ho Lee,Dae-Sik Lim +13 more
TL;DR: It is reported that the Hippo pathway controls liver cell lineage specification and proliferation separately from Notch signalling, using mice and primary hepatoblasts with liver-specific knockout of Lats1 and Lats2 kinase, the direct upstream regulators of YAP and TAZ.
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Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma.
Byung-Soo Lee,Dong Il Park,Da Hye Lee,Jeong Eun Lee,Min-Kyung Yeo,Yeon Hee Park,Dae-Sik Lim,Wonyoung Choi,Geon Yoo,Hanbyul Kim,Dahyun Kang,Jae Young Moon,Sung Soo Jung,Ju Ock Kim,Sang Yeon Cho,Hee Sun Park,Chaeuk Chung +16 more
TL;DR: Surprisingly, knockdown of PD-L1 was sufficient to decrease cell proliferation and wound healing in the EGFR-TKI-resistant PC9 cells, suggesting a PD1-independent oncogenic function of PD -L1.
Journal ArticleDOI
Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice
Hoogeun Song,Hyun-Soo Kim,Kyung Hee Lee,Da Hye Lee,Tae Shin Kim,Ji Yun Song,Dongjun Lee,Dongwook Choi,Chang Yong Ko,Hansung Kim,Hong In Shin,Juhyun Choi,Hee-Dong Park,Chankyu Park,Daewon Jeong,Dae-Sik Lim +15 more
TL;DR: It is shown that Rassf2 knockout mice manifest a multisystemic phenotype including haematopoietic anomalies and defects in bone remodelling and that RASSF2 regulates osteoblast and osteoclast differentiation by inhibiting NF‐κB signalling.
Journal ArticleDOI
Circulating regulatory T cells predict efficacy and atypical responses in lung cancer patients treated with PD-1/PD-L1 inhibitors
Da Hyun Kang,Chaeuk Chung,Pureum Sun,Da Hye Lee,Song-I Lee,Dong Il Park,Jeong Suk Koh,Yoonjoo Kim,Hyon-Seung Yi,Jeong Eun Lee +9 more
TL;DR: In this paper, the frequency of pseudoprogression and hyperprogression in lung cancer patients treated with ICIs in the real world and aimed to discover a novel candidate marker to distinguish pseudOProgression from hyper-progression soon after ICI treatment.