Chaeuk Chung

TL;DR: It is proposed that Yap responds to Cdc42-dependent signals in nephron progenitor cells to activate a genetic program required to shape the functioning nephrons, in a manner independent of regulation of cell proliferation and apoptosis.

TL;DR: It is reported here that toll-like receptor (TLR) 4-mediated inflammatory signaling molecules are upregulated in peripheral blood mononuclear cells from COVID-19 patients, compared with healthy controls (HC).

TL;DR: Surprisingly, knockdown of PD-L1 was sufficient to decrease cell proliferation and wound healing in the EGFR-TKI-resistant PC9 cells, suggesting a PD1-independent oncogenic function of PD -L1.

TL;DR: This study shows that Mtb significantly induces the expression of MIR144*/hsa-miR-144-5p, which targets the 3′-untranslated region of DRAM2 (DNA damage regulated autophagy modulator 2) in human monocytes and macrophages, and reveals that DR AM2 is a key coordinator of autophagic activation that enhances antimicrobial activity against Mtb.

TL;DR: Understanding the mechanisms and key players involved in modulating antibacterial autophagy will provide innovative improvements in anti-TB therapy via an autophophagy-targeting approach.