Sung Soo Jung

TL;DR: IL-10, although inhibiting lipopolysaccharide-induced inflammation, also causes mucus metaplasia, tissue inflammation, and airway fibrosis, and these responses are mediated by multiple mechanisms with mucusMetaplasia being dependent on and the inflammation and fibrosis being independent of an IL-13/IL-4Rα/STAT-6 activation pathway.

TL;DR: It is demonstrated that the 38-kDa glycolipoprotein, acting through both TLR2 and TLR4, induces the activation of the ERK1/2 and p38 MAPK pathways, which in turn play an essential role in TNF-α and IL-6 expression during mycobacterial infection.

TL;DR: Surprisingly, knockdown of PD-L1 was sufficient to decrease cell proliferation and wound healing in the EGFR-TKI-resistant PC9 cells, suggesting a PD1-independent oncogenic function of PD -L1.

TL;DR: This study shows that Mtb significantly induces the expression of MIR144*/hsa-miR-144-5p, which targets the 3′-untranslated region of DRAM2 (DNA damage regulated autophagy modulator 2) in human monocytes and macrophages, and reveals that DR AM2 is a key coordinator of autophagic activation that enhances antimicrobial activity against Mtb.

TL;DR: The findings suggest that the molecular mechanisms and genes involved in ATRA-induced differentiation of APL cells may be different and cell type specific, and further studies will be needed to define the important molecular pathways involved in granulocytic differentiation by ATRA in APl cells.