Dana M. Ambruzs

TL;DR: It is demonstrated that a slowly cycling stem cell population exists within the intestine and that mTert+ cells give rise to all differentiated intestinal cell types, persist long term, and contribute to the regenerative response following injury.

TL;DR: Enriched ICs, when encapsulated and implanted into mice, functioned similarly to the VC‐01 candidate product, demonstrating conclusively that in vitro‐produced hESC‐derived insulin‐producing cells can mature and function in vivo in devices.

TL;DR: Together, these data provide direct evidence that mTert-GFP expression marks progenitor cells in blood and small intestine, validating these mice as a useful tool for the prospective identification, isolation, and functional characterization of progenitors/stem cells from multiple tissues.

TL;DR: It is shown that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is an important regulator of dormant intestinal stem cells (d-ISCs) and that intestines lacking PTEN have diminished regenerative capacity after irradiation.

TL;DR: In this article, the role of mTert−expressing cells in postnatal mouse long bone was investigated and it was found that mTERT expression is enriched at the time of adolescent bone growth.