M
Manasvi S. Shah
Researcher at Boston Children's Hospital
Publications - 25
Citations - 855
Manasvi S. Shah is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Stem cell & microRNA. The author has an hindex of 12, co-authored 22 publications receiving 667 citations. Previous affiliations of Manasvi S. Shah include Texas A&M University & Harvard University.
Papers
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Journal ArticleDOI
n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon
Laurie A. Davidson,Naisyin Wang,Manasvi S. Shah,Joanne R. Lupton,Ivan Ivanov,Robert S. Chapkin +5 more
TL;DR: The utility of the rat AOM model and the novel role of fish oil in protecting the colon from carcinogen-induced miRNA dysregulation are demonstrated for the first time.
Journal ArticleDOI
Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells
Bethany D. Freedman,Bethany D. Freedman,Petra Bukovac Kempna,Petra Bukovac Kempna,Diana L. Carlone,Diana L. Carlone,Manasvi S. Shah,Manasvi S. Shah,Nick A. Guagliardo,Paula Q. Barrett,Celso E. Gomez-Sanchez,Joseph A. Majzoub,Joseph A. Majzoub,David T. Breault,David T. Breault +14 more
TL;DR: It is demonstrated that adrenocortical zonation and regeneration result from lineage conversion and may provide a paradigm for homeostatic cellular renewal in other tissues.
Journal ArticleDOI
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation
Chaiyaboot Ariyachet,Alessio Tovaglieri,Guanjue Xiang,Jiaqi Lu,Manasvi S. Shah,Manasvi S. Shah,Camilla A. Richmond,Camilla A. Richmond,Catia S. Verbeke,Douglas A. Melton,Ben Z. Stanger,David J. Mooney,Ramesh A. Shivdasani,Shaun Mahony,Qing Xia,David T. Breault,David T. Breault,Qiao Zhou +17 more
TL;DR: It is shown that cells of the antral stomach have a previously unappreciated propensity for conversion into functional insulin-secreting cells, highlighting the potential for development of engineered stomach tissues as a renewable source of functional β cells for glycemic control.
Journal ArticleDOI
Dormant Intestinal Stem Cells are Regulated by PTEN and Nutritional Status
Camilla A. Richmond,Manasvi S. Shah,Luke T. Deary,Danny C. Trotier,Horatio R. Thomas,Horatio R. Thomas,Dana M. Ambruzs,Lijie Jiang,Bristol B. Whiles,Hannah Rickner,Robert K. Montgomery,Robert K. Montgomery,Alessio Tovaglieri,Diana L. Carlone,David T. Breault,David T. Breault +15 more
TL;DR: It is shown that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is an important regulator of dormant intestinal stem cells (d-ISCs) and that intestines lacking PTEN have diminished regenerative capacity after irradiation.
Journal ArticleDOI
Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet
Manasvi S. Shah,Scott Schwartz,Chen Zhao,Laurie A. Davidson,Beiyan Zhou,Joanne R. Lupton,Ivan Ivanov,Robert S. Chapkin +7 more
TL;DR: It is demonstrated that polysomal profiling is tightly related to microRNA changes when compared with total mRNA profiling and linear discriminant analysis was used to identify the best single-, two-, and three-microRNA combinations for classifying dietary effects and colon tumor development.