C
Christopher J. Lengner
Researcher at University of Pennsylvania
Publications - 133
Citations - 12605
Christopher J. Lengner is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Stem cell & Wnt signaling pathway. The author has an hindex of 47, co-authored 107 publications receiving 11054 citations. Previous affiliations of Christopher J. Lengner include Cardiovascular Institute of the South & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Tripti Gaur,Christopher J. Lengner,Hayk Hovhannisyan,Ramesh A. Bhat,Peter V.N. Bodine,Barry S. Komm,Amjad Javed,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +10 more
TL;DR: It is proposed that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-β signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development.
Journal ArticleDOI
Direct cell reprogramming is a stochastic process amenable to acceleration
Jacob H. Hanna,Krishanu Saha,Bernardo F. Pando,Jeroen S. van Zon,Christopher J. Lengner,Menno P. Creyghton,Alexander van Oudenaarden,Rudolf Jaenisch +7 more
TL;DR: Quantitative analyses define distinct cell-division-rate-dependent and -independent modes for accelerating the stochastic course of reprogramming, and suggest that the number of cell divisions is a key parameter driving epigenetic reprograming to pluripotency.
Journal ArticleDOI
Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells
Tobias Brambrink,Ruth K. Foreman,G. Grant Welstead,Christopher J. Lengner,Marius Wernig,Heikyung Suh,Rudolf Jaenisch +6 more
TL;DR: Using inducible constructs derived induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) and found that transgene silencing is a prerequisite for normal cell differentiation, a step toward understanding some of the molecular events governing epigenetic reprogramming.
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Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency
Jacob H. Hanna,Styliani Markoulaki,Patrick Schorderet,Bryce W. Carey,Caroline Beard,Marius Wernig,Menno P. Creyghton,Eveline J. Steine,John P. Cassady,Ruth K. Foreman,Christopher J. Lengner,Jessica Dausman,Rudolf Jaenisch +12 more
TL;DR: This study provides definite proof for the direct nuclear reprogramming of terminally differentiated adult cells to pluripotency through transgenic and inducible expression of transcription factors.
Journal ArticleDOI
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
Jacob H. Hanna,Albert W. Cheng,Krishanu Saha,Jongpil Kim,Christopher J. Lengner,Frank Soldner,John P. Cassady,Julien Muffat,Bryce W. Carey,Rudolf Jaenisch +9 more
TL;DR: The generation of validated “naïve” human ESCs will allow the molecular dissection of a previously undefined pluripotent state in humans and may open up new opportunities for patient-specific, disease-relevant research.