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Daniel Brian Nichols
Researcher at Seton Hall University
Publications - 13
Citations - 208
Daniel Brian Nichols is an academic researcher from Seton Hall University. The author has contributed to research in topics: NS5B & Molluscum contagiosum virus. The author has an hindex of 8, co-authored 13 publications receiving 176 citations. Previous affiliations of Daniel Brian Nichols include Rutgers University.
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Journal ArticleDOI
Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis.
TL;DR: This review considers anti-apoptotic strategies of poxviruses focusing on three relevant poxvirus genera: Orthopoxv virus, Molluscipoxvirus, and Leporipox virus, which express multiple products to inhibit both extrinsic and intrinsic apoptotic pathways with many of these products required for virulence.
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2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase
İlkay Küçükgüzel,Gökhan Satılmış,K.R. Gurukumar,Amartya Basu,Esra Tatar,Daniel Brian Nichols,Tanaji T. Talele,Neerja Kaushik-Basu +7 more
TL;DR: The design, synthesis and evaluation of twenty-four novel allosteric inhibitors bearing the 4-thiazolidinone scaffold as inhibitors of HCV NS5B polymerase suggest that further optimization of the thiazolidine scaffold may be possible to yield new derivatives with improved enzyme- and cell-based activity.
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Synthesis and characterization of flurbiprofen hydrazide derivatives as potential anti-HCV, anticancer and antimicrobial agents
Pelin Cikla,Esra Tatar,İlkay Küçükgüzel,Fikrettin Sahin,Dilsad Yurdakul,Amartya Basu,Ramalingam Krishnan,Daniel Brian Nichols,Neerja Kaushik-Basu,Ş. Güniz Küçükgüzel +9 more
TL;DR: None of the compounds tested have anticandidal and antifungal activities, but two of them (4a and 4i) showed antibacterial inhibition against Micrococcus luteus, and Staphylococcus cohnii and StAPHylococus aureus, respectively.
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Evaluation of coumarin and neoflavone derivatives as HCV NS5B polymerase inhibitors.
Daniel Brian Nichols,Raquel A. C. Leão,Amartya Basu,Maksim Chudayeu,Paula de F. de Moraes,Tanaji T. Talele,Paulo R. R. Costa,Neerja Kaushik-Basu +7 more
TL;DR: The NS5B‐TP‐1‐8a interaction map provided insight into 8a binding and offered clues for future SAR optimization, and the newly synthesized 6,8‐diallyl‐5,7‐dihydroxycoumarin (8a) was found to be the most potent of this series, exhibiting activity similar to the reference coumestan LQB‐34.
Journal ArticleDOI
Inhibition of Hepatitis C Virus NS5B Polymerase by S-Trityl-L-Cysteine Derivatives
Daniel Brian Nichols,Guy Fournet,K.R. Gurukumar,Amartya Basu,Jin-Ching Lee,Naoya Sakamoto,Frank Kozielski,Ira Musmuca,Benoît Joseph,Rino Ragno,Neerja Kaushik-Basu +10 more
TL;DR: Binding mode investigations suggested that the STLC scaffold can be used to develop new NS5B inhibitors by further chemical modification at one of the trityl phenyl group.