D
Daniel C. Chung
Researcher at Harvard University
Publications - 307
Citations - 27050
Daniel C. Chung is an academic researcher from Harvard University. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 69, co-authored 290 publications receiving 24211 citations. Previous affiliations of Daniel C. Chung include University of Pennsylvania & Google.
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Journal ArticleDOI
The human visual cortex responds to gene therapy-mediated recovery of retinal function.
Manzar Ashtari,Laura Cyckowski,Justin F. Monroe,Kathleen A. Marshall,Daniel C. Chung,Alberto Auricchio,Francesca Simonelli,Bart P. Leroy,Albert M. Maguire,Kenneth S. Shindler,Jean Bennett +10 more
TL;DR: Functional MRI data suggest that despite severe and long-term visual impairment, treated LCA2 patients have intact and responsive visual pathways, and suggest that gene therapy resulted in not only sustained and improved visual ability, but also enhanced contrast sensitivity.
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LKB1--a master tumour suppressor of the small intestine and beyond.
TL;DR: This work has shown the molecular mechanisms by which LKB1 functions as an important new tumour suppressor in Peutz–Jeghers syndrome.
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Germline Mutations in Oncogene-Induced Senescence Pathways Are Associated With Multiple Sessile Serrated Adenomas
Manish Gala,Yusuke Mizukami,Long P. Le,Kentaro Moriichi,Thomas R. Austin,Masayoshi Yamamoto,Gregory Y. Lauwers,Nabeel Bardeesy,Daniel C. Chung +8 more
TL;DR: RNF43 is identified as a regulator of the DNA damage response and associated nonsense variants in this gene with a high risk of developing SSAs are associated with germline loss-of-function variants in genes that regulate senescence pathways with the development of multiple SSAs.
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Prevalence of Thyroid Cancer in Familial Adenomatous Polyposis Syndrome and the Role of Screening Ultrasound Examinations
M Herráiz,Giuseppe Barbesino,William C. Faquin,Gayun Chan–Smutko,Devanshi Patel,Kristen M. Shannon,Gilbert H. Daniels,Daniel C. Chung +7 more
TL;DR: The 12% prevalence of thyroid cancer in this series of FAP patients is significantly higher than in previous reports and close follow-up with ultrasound and fine-needle aspiration might be warranted.
Journal ArticleDOI
Leber congenital amaurosis: clinical correlations with genotypes, gene therapy trials update, and future directions.
TL;DR: A review of clinical presentation and disease course, their correlation to specific genotypes, and underlying physiological mechanisms, coupled with the latest results of human gene therapy trials, will assist the clinician in patient diagnosis and counseling.