Daniel C. Chung

TL;DR: The key features of normal DNA replication and the mechanisms that ensure the fidelity of this process are highlighted, and the genes involved in DNA mismatch repair are illustrated.

TL;DR: Recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27 are identified, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs.

TL;DR: Hif1A expression is independently associated with poor prognosis in colorectal cancer, suggesting HIF1A as a biomarker with potentially important therapeutic implications, and EPAS1 expression was not significantly associated with patient survival.

TL;DR: The data demonstrate that AAV2.RPE65 delivers the RPE65 transgene efficiently and quickly to the appropriate target cells in vivo in animal models, and holds great promise for treatment of LCA due to R PE65 mutations.

TL;DR: The most pressing needs were public and physician education, identification of molecular markers for early diagnosis and therapeutic monitoring, improved imaging modalities and molecular prognostication, development of a standardized pathological classification system, and creation of regional centers of expertise with tumor and laboratory data banks.