Showing papers in "Clinical Gastroenterology and Hepatology in 2007"

TL;DR: The prevalence of Crohn's disease and ulcerative colitis in a large national sample and to compare the prevalence across geographic regions and other sociodemographic characteristics should help quantify the overall burden of disease and inform the planning of appropriate clinical services.

TL;DR: MR elastography is a safe, noninvasive technique with excellent diagnostic accuracy for assessing liver fibrosis and an initial clinical application may be to triage patients who are under consideration for biopsy examination to assess possible hepatic fibrosis.

TL;DR: The prognosis for CD seems better than previously reported, the probability of surgery was low, and fewer than expected developed complicated disease behavior, and the finding of prognostic risk factors for subsequent surgery might call for attention to early effective medical treatment strategies.

TL;DR: The short-term colectomy rate in severe UC has remained stable during the last 30 years, despite the introduction of cyclosporine, which was not used frequently and could not find any support for administering methylprednisolone at a higher dose than 60 mg/day.

TL;DR: Ultrasound-based transient elastography appears to be a clinically useful test for detecting cirrhosis.

TL;DR: CDAD incidence in IBD has increased and is higher than in the non-IBD population and IBD and UC patients in particular have a higher risk for CDAD.

TL;DR: Increased vigilance regarding this infection in IBD patients with colitis activity is warranted and maintenance immunomodulator use and colonic involvement as independent risk factors for C difficile infection inIBD are identified.

TL;DR: This work has classified drugs that have been reported to cause acute pancreatitis based on the published weight of evidence for each agent and the pattern of clinical presentation, and identified 4 classes of drugs.

TL;DR: Several novel associations with ECC and ICC were identified, including HCV infection, chronic nonalcoholic liver disease, and obesity, all of which are increasing in incidence, and smoking, which were associated only with ICC.

TL;DR: There is evidence that the prevalence of GERD has increased during the past 2 decades, and if this trend continues, it could contribute to the rapidly increasing incidence of more serious complications associated with GERD, as well as costs to healthcare systems and employers.

TL;DR: ESD is applicable in the colorectum with promising results, however, when considering the risks and benefits, piecemeal endoscopic resection or coloreCTal resection might be more appropriate for some subgroups of large flat neoplasms or those with submucosal fibrosis.

TL;DR: Low pretreatment HBsAg is better than HBV DNA to predict good response to peginterferon and lamivudine treatment, and levels correlate well with the cccDNA and intrahepatic HBVDNA.

TL;DR: Biofeedback improves constipation and physiologic characteristics of bowel function in patients with dyssynergia, mediated by modifying physiologic behavior and colorectal function.

TL;DR: Weight loss and male sex were highly predictive of refractory CD and a limited number of etiologies account for the majority of cases, which is a common phenomenon affecting 10%-19% of celiac patients.

TL;DR: This study shows that T ACE using DEB is a safe and effective treatment for HCC, supporting a phase III randomized trial to compare this novel treatment with conventional TACE using doxorubicin-Lipiodol emulsion.

TL;DR: MMX mesalamine given once or twice daily is well-tolerated and, compared with placebo, demonstrated efficacy for the induction of clinical and endoscopic remission in mild to moderately active ulcerative colitis.

TL;DR: The results suggest that symptomatic patients with sclerosing mesenteritis might benefit from medical therapy, particularly tamoxifen and prednisone combination treatment.

TL;DR: An international group of experienced hepatologists and virologists conducted a single-day workshop to review the management of patients with chronic hepatitis B receiving treatment with oral nucleosides or nucleotides, recommending monitoring of serum HBV DNA levels to identify outcomes of therapy.

TL;DR: The new classification for duodenal pathology in celiac disease gives better interobserver agreement compared with the more cumbersome Marsh-Oberhuber classification and contributes to the validity of diagnosis in Celiac disease.

TL;DR: An improved fecal DNA test that incorporates only 2 markers shows much higher sensitivity for CRC and is easier to perform and should be less costly, thereby facilitating its use for noninvasive CRC screening.

TL;DR: Duodenal eosinophilia may characterize a subset of adults with non-ulcer dyspepsia, and early satiety was associated with eos inophilia in D1 (P = .01) and D2 (P= .02), adjusting for age, sex, and H pylori.

TL;DR: An important role for COX-2 in the maintenance of small-bowel integrity is suggested, which has implications for strategies that aim to minimize the gastrointestinal damage in patients requiring anti-inflammatory analgesics.

TL;DR: 6 important predictors of hepatocellular carcinoma have been identified in multivariate models (including relatively novel predictors such as increased body mass index, HBV core antibody, and low platelet count), which suggest a means of predicting the risk of hepatitis C virus infection in patients with cirrhosis and optimizing surveillance strategies.

TL;DR: C celiac disease-associated serum IgG and HLA-DQ2 expression can identify likely responders to gluten-free diet in d-IBS patients.

TL;DR: Autoimmune enteropathy is a heterogeneous disease and should be considered in the differential diagnosis of malabsorption and small bowel villous atrophy and immunosuppressive therapy is required in most cases.

TL;DR: PI-IBS is common after presumptive viral gastroenteritis but might be more transient than after bacterial dysentery, and the prevalence of IBS was similar among exposed versus nonexposed individuals.

TL;DR: In this article, a systematic review of randomized controlled trials (RCTs) was conducted to assess the upper gastrointestinal harms of the long-term use of COX-2s, compared with non-steroidal anti-inflammatory drugs (NSAIDs) and placebo, in arthritis sufferers.

TL;DR: Chronic HBV infection is associated with significant preventable excess mortality risk and this mortality risk is correlated strongly with the level of viral replication among other factors.

TL;DR: The addition of allopurinol to thiopurine nonresponders with high 6-MMP metabolite levels is an effective and safe means of optimizing 6-TGN production, leading to improved disease activity scores, reduced corticosteroid requirements, and normalization of liver enzymes.

TL;DR: Treatment of Narcotic bowel syndrome involves early recognition of the syndrome, an effective physician-patient relationship, graded withdrawal of the narcotic according to a specified withdrawal program, and the institution of medications to reduce withdrawal effects.