D
Daniel C. Rowe
Researcher at University of Massachusetts Medical School
Publications - 10
Citations - 6038
Daniel C. Rowe is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Signal transduction & Receptor. The author has an hindex of 9, co-authored 10 publications receiving 5584 citations.
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Journal ArticleDOI
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Katherine A. Fitzgerald,Sarah M. McWhirter,Kerrie L. Faia,Daniel C. Rowe,Eicke Latz,Douglas T. Golenbock,Anthony J. Coyle,Sha-Mei Liao,Tom Maniatis +8 more
TL;DR: It is reported that the noncanonical IκB kinase homologs, IKKε (IKKε) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-κB activation, are also essential components of the IRF3 signaling pathway.
Journal ArticleDOI
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Katherine A. Fitzgerald,Daniel C. Rowe,Betsy J. Barnes,Daniel R. Caffrey,Alberto Visintin,Eicke Latz,Brian G. Monks,Paula M. Pitha,Douglas T. Golenbock +8 more
TL;DR: These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS.
Journal ArticleDOI
HMGB1 and RAGE in inflammation and cancer.
TL;DR: The role of the HMGB1-RAGE axis in inflammation and cancer is reviewed, which has been implicated in sterile inflammation as well as in cancer, diabetes, and Alzheimer's disease.
Journal ArticleDOI
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
Sarah M. McWhirter,Katherine A. Fitzgerald,Jacqueline Rosains,Daniel C. Rowe,Douglas T. Golenbock,Tom Maniatis +5 more
TL;DR: It is concluded that TBK1 is essential for IRF3-dependent antiviral gene expression after infection with either Sendai or Newcastle disease viruses or after engagement of the Toll-like receptors 3 and 4 by double-stranded RNA and lipopolysaccharide.
Journal ArticleDOI
Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
TL;DR: Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2, which provides a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.