G
Gary P. Sims
Researcher at MedImmune
Publications - 27
Citations - 2356
Gary P. Sims is an academic researcher from MedImmune. The author has contributed to research in topics: RAGE (receptor) & Proinflammatory cytokine. The author has an hindex of 14, co-authored 27 publications receiving 1990 citations. Previous affiliations of Gary P. Sims include AstraZeneca.
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Journal ArticleDOI
HMGB1 and RAGE in inflammation and cancer.
TL;DR: The role of the HMGB1-RAGE axis in inflammation and cancer is reviewed, which has been implicated in sterile inflammation as well as in cancer, diabetes, and Alzheimer's disease.
Journal ArticleDOI
Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease
Nassima Ferhani,Séverine Létuvé,Alexander Kozhich,Olivier Thibaudeau,Martine Grandsaigne,Marielle Maret,Marie-Christine Dombret,Gary P. Sims,Roland Kolbeck,Anthony J. Coyle,Michel Aubier,Marina Pretolani +11 more
TL;DR: Elevated HMGB1 expression in COPD airways may sustain inflammation and remodeling through its interaction with IL-1beta and RAGE.
Journal ArticleDOI
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
Cherilyn M. Sirois,Cherilyn M. Sirois,Tengchuan Jin,Allison L. Miller,Damien Bertheloot,Hirotaka Nakamura,Gabor Horvath,Gabor Horvath,Abubakar Mian,Jiansheng Jiang,Jacob E. Schrum,Lukas Bossaller,Karin Pelka,Natalio Garbi,Yambasu A. Brewah,Jane Tian,Chew-Shun Chang,Partha S. Chowdhury,Gary P. Sims,Roland Kolbeck,Anthony J. Coyle,Anthony J. Coyle,Alison A. Humbles,T. Sam Xiao,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: Receptor for advanced glycation end-products (RAGE) detects nucleic acids and promotes DNA uptake into endosomes, which in turn lowers the immune recognition threshold for TLR9 activation.
Journal ArticleDOI
B cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody
Ronald Herbst,Yue Wang,Sandra Gallagher,Nanette Mittereder,Ellen Kuta,Melissa Damschroder,Robert M. Woods,Daniel C. Rowe,Li Cheng,Kim Cook,Krista Evans,Gary P. Sims,David Pfarr,Michael A. Bowen,William Dall'acqua,Mark J. Shlomchik,Thomas F. Tedder,Peter A. Kiener,Bahija Jallal,Herren Wu,Anthony J. Coyle +20 more
TL;DR: Afucosylated CD19 mAb MEDI-551 has potent B-cell-depleting activity in vitro and in vivo and may be a promising new approach for the treatment of B- cell malignancies and autoimmune diseases.
Journal ArticleDOI
Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.
Hans P. Kiener,Gerald F. Watts,Yajun Cui,John Wright,Thomas S. Thornhill,Markus Sköld,Samuel M. Behar,Birgit Niederreiter,Jun Lu,Manuela Cernadas,Anthony J. Coyle,Gary P. Sims,Josef S Smolen,Matthew L. Warman,Michael B. Brenner,David M. Lee +15 more
TL;DR: 3-D micromass organ culture method demonstrates that many of the phenotypic characteristics of the normal and the hyperplastic synovial lining in vivo are intrinsic functions of FLS, and provides new insight into inherent functions of the FLS lineage.