S
Svend T. Rietdijk
Researcher at Beth Israel Deaconess Medical Center
Publications - 21
Citations - 1958
Svend T. Rietdijk is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Receptor & T cell. The author has an hindex of 9, co-authored 19 publications receiving 1749 citations.
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Journal ArticleDOI
HMGB1 and RAGE in inflammation and cancer.
TL;DR: The role of the HMGB1-RAGE axis in inflammation and cancer is reviewed, which has been implicated in sterile inflammation as well as in cancer, diabetes, and Alzheimer's disease.
Journal ArticleDOI
Homotypic Interactions Mediated by Slamf1 and Slamf6 Receptors Control NKT Cell Lineage Development
Klaus G. Griewank,Christine Borowski,Svend T. Rietdijk,Ninghai Wang,Aimée Julien,Datsen G. Wei,Alusha A. Mamchak,Cox Terhorst,Albert Bendelac +8 more
TL;DR: The topography of N KT cell ligand recognition determines the availability of a cosignaling pathway that is essential for NKT cell lineage development.
Journal ArticleDOI
Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells
Massimo Morra,Jun Lu,Florence Poy,Margarita Martin,Joan Sayós,Silvia Calpe,Charles A. Gullo PhD,Duncan Howie,Svend T. Rietdijk,Andrew J. Thompson,Anthony J. Coyle,Christopher Denny,Michael B. Yaffe,Pablo Engel,Michael J. Eck,Cox Terhorst +15 more
TL;DR: It is reported that a second gene encoding a free SH2 domain, EAT‐2, is expressed in macrophages and B lympho cytes and plays a role in controlling signal transduction through at least four receptors expressed on the surface of professional antigen‐presenting cells.
Journal ArticleDOI
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon γ production
Duncan Howie,Susumo Okamoto,Svend T. Rietdijk,Kareem Clarke,Ninghai Wang,Charles A. Gullo PhD,Joost P. Bruggeman,Stephen Manning,Anthony J. Coyle,Edward A. Greenfield,Vijay K. Kuchroo,Cox Terhorst +11 more
TL;DR: A panel of rat antimouse CD150 monoclonal antibodies is generated and it is speculated that this is an important pathway contributing to CD150-mediated T-cell proliferation.
Journal ArticleDOI
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction.
TL;DR: Using bone-marrow chimeras, it is found that the signaling molecules SAP, Fyn, and PKCtheta were essential for T-CD4 T cell generation, whereas mutations in the Ly108 receptor, interleukin-15 receptor alpha, or the transcription factor T-bet had a marginal effect.