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Daniel C. Williams
Researcher at Eli Lilly and Company
Publications - 27
Citations - 2923
Daniel C. Williams is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Cell culture & Estrogen. The author has an hindex of 17, co-authored 27 publications receiving 2852 citations.
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Journal ArticleDOI
Increased osteoclast development after estrogen loss: mediation by interleukin-6
Robert L. Jilka,Giao Hangoc,Giuseppe Girasole,Giovanni Passeri,Daniel C. Williams,John S. Abrams,Brendan F. Boyce,Hal E. Broxmeyer,Stavros C. Manolagas +8 more
TL;DR: Estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.
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Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells
Robert Frank Santerre,Roland A. Cook,Rae Marie D. Crisel,John D. Sharp,Robert J. Schmidt,Daniel C. Williams,Christine P. Wilson +6 more
TL;DR: The HIT cell line represents a unique in vitro system for studying beta cell metabolism and insulin biosynthesis and was established by simian virus 40 transformation of Syrian hamster pancreatic islet cells.
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Cytoplasmic inclusion bodies in Escherichia coli producing biosynthetic human insulin proteins
TL;DR: Escherichia coli that has been genetically manipulated by recombinant DNA technology to synthesize human insulin polypeptides (A chain, B chain, or proinsulin) contains prominent cytoplasmic inclusion bodies.
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Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption.
Robert L. Jilka,K Takahashi,Medha Munshi,Daniel C. Williams,Paula K. Roberson,Stavros C. Manolagas +5 more
TL;DR: It is reported that the number of mesenchymal osteoblast progenitors in the murine bone marrow was increased two- to threefold between 2 and 8 wk after ovariectomy and returned to control levels by 16 wk, indicating that the increased bone formation that follows loss of estrogen can be explained, at least in part, by an increase in osteobnightogenesis.
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Isolation and characterization of insulin-like growth factor-II from human bone.
TL;DR: In addition to several known growth factors already reported to be present in bone, insulin-like growth factor-II was identified by its chromatographic, electrophoretic and immunological properties as well as by N-terminal sequence data.