G
Giao Hangoc
Researcher at Indiana University – Purdue University Indianapolis
Publications - 22
Citations - 2682
Giao Hangoc is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 17, co-authored 22 publications receiving 2533 citations. Previous affiliations of Giao Hangoc include Tokyo Medical University & Indiana University.
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Journal ArticleDOI
Increased osteoclast development after estrogen loss: mediation by interleukin-6
Robert L. Jilka,Giao Hangoc,Giuseppe Girasole,Giovanni Passeri,Daniel C. Williams,John S. Abrams,Brendan F. Boyce,Hal E. Broxmeyer,Stavros C. Manolagas +8 more
TL;DR: Estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.
Journal ArticleDOI
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Charlie Mantel,Heather O'Leary,Brahmananda R. Chitteti,Xinxin Huang,Scott Cooper,Giao Hangoc,Nickolay Brustovetsky,Edward F. Srour,Man Ryul Lee,Man Ryul Lee,Steve Messina-Graham,David M. Haas,Nadia Falah,Reuben Kapur,Louis M. Pelus,Nabeel Bardeesy,Julien Fitamant,Mircea Ivan,Kye Seong Kim,Hal E. Broxmeyer +19 more
TL;DR: In this article, the extraphysiologic oxygen shock/stress (EPHOSS) phenomenon was found to decrease the recovery of long-term repopulating HSCs and increase progenitor cells.
Journal ArticleDOI
High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years.
Hal E. Broxmeyer,Edward F. Srour,Giao Hangoc,Scott Cooper,Stacie A. Anderson,David M. Bodine +5 more
TL;DR: In this article, the authors assessed the efficiency of recovery of viable HSC/HPC from individual cord blood (CB) stored frozen for 15 years, using the same culture conditions as for pre-freeze samples, and showed that immature human CB cells with high proliferative, replating, ex vivo expansion and mouse NOD/SCID engrafting ability can be efficiently retrieved, and most likely remain effective for clinical transplantation.
Journal ArticleDOI
Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines.
Younghee Lee,Akihiko Gotoh,Akihiko Gotoh,Hyung-Joo Kwon,Hyung-Joo Kwon,Minute You,Minute You,Lisa L. Kohli,Lisa L. Kohli,Charlie Mantel,Charlie Mantel,Scott Cooper,Scott Cooper,Giao Hangoc,Giao Hangoc,Keisuke Miyazawa,Keisuke Miyazawa,Kazuma Ohyashiki,Kazuma Ohyashiki,Hal E. Broxmeyer +19 more
TL;DR: SDF-1 may contribute to maintenance of MPCs in bone marrow by enhancing cell survival alone and in combination with other cytokines, and was synergistically enhanced when SDF- 1 alpha was combined with low amounts of other survival-promoting cytokines.
Journal ArticleDOI
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice.
TL;DR: Inhibition of CD26 peptidase activity may be one way to enhance engraftment of limiting numbers of stem cells during CB transplantation, as measured phenotypically by human markers CD33, CD38, CD19, and CD34.