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Giuseppe Girasole

Researcher at Veterans Health Administration

Publications -  9
Citations -  2274

Giuseppe Girasole is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Osteoclast & Stromal cell. The author has an hindex of 7, co-authored 7 publications receiving 2216 citations. Previous affiliations of Giuseppe Girasole include Indiana University – Purdue University Indianapolis & Indiana University.

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Journal ArticleDOI

Increased osteoclast development after estrogen loss: mediation by interleukin-6

Robert L. Jilka, +8 more
- 03 Jul 1992 - 
TL;DR: Estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.
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Interleukin-11: a new cytokine critical for osteoclast development.

Giuseppe Girasole, +3 more
- 01 Apr 1994 - 
TL;DR: It is reported here that IL-11, a newly discovered cytokine that is produced by marrow stromal cells, induced the formation of osteoclasts exhibiting an unusually high degree of ploidy in cocultures of murine bone marrow and calvarial cells.
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Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal

Giovanni Passeri, +3 more
- 01 Aug 1993 - 
TL;DR: It is established that estrogen loss causes an up-regulation of IL-6 production by bone marrow cells and that a similar phenomenon can be elicited in vitro by withdrawal of 17 beta-estradiol from primary cultures of bone cells.
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Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3

Teresita Bellido, +7 more
- 01 Aug 1993 - 
TL;DR: It is found that bone marrow-derived stromal cells express functional estrogen as well as vitamin D receptors, which serve to mediate actions of their respective ligands on the biosynthetic activity of these cells and presumably the effects of these two steroid hormones on osteoclastogenesis.
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Endogenous production of tumor necrosis factor by primary cultures of murine calvarial cells: influence on IL-6 production and osteoclast development.

Giovanni Passeri, +7 more
- 01 Feb 1994 - 
TL;DR: It is suggested that TNF, but not IL-1, is produced by murine bone cells and that endogenous TNF induces the IL-6 production, osteoclast formation, and bone resorption exhibited by these cultures under basal conditions.